NKT CELLS AS MODULATORS OF IMMUNE ACTIVATION IN SOOTY MANGABEYS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 自然杀伤T淋巴细胞(Natural Killer T，NKT)是一种独特的T淋巴细胞亚群，具有不变的TCR Valpha链，可识别非多态CD1d分子所呈现的配体。在功能上，CD1d反应性NKT细胞可以分泌大量的Th-1和Th-2类细胞因子，包括IL-10，是先天免疫系统的早期效应者。通过分泌多种细胞因子，NKT细胞可能在调节HIV和SIV感染的免疫激活中发挥作用。煤烟山竹是SIV的自然宿主，不会发展为艾滋病。在其自然宿主中，SIV感染的一个关键区别特征是没有异常的免疫激活。在这个项目中，我们正在调查NKT细胞是否对自然感染SIV的煤色芒果缺乏异常免疫激活负责。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Natural Killer T (NKT) lymphocytes are a unique subset of T lymphocytes that have an invariant TCR Valpha chain and recognize ligands presented by the nonpolymorphic CD1d molecule. Functionally, CD1d-reactive NKT cells can secrete large amounts of both Th-1 and Th-2 type cytokines, including IL-10, and are early effectors of the innate immune system. By virtue of the diverse cytokines that they secrete, NKT cells may play a role in modulating immune activation in HIV and SIV infection. Sooty mangabeys are a natural host of SIV that do not progress to AIDS. A key differentiating feature of SIV infection in its natural host is the absence of aberrant immune activation. In this project we are investigating whether NKT cells are responsible for the lack of aberrant immune activation in naturally SIV-infected sooty mangabeys.