CHARACTERIZATION OF MHC CLASS I ALLELES IN SOOTY MANGABEYS

乌白眉猴 MHC I 类等位基因的特征

• 批准号: 8357924
• 负责人: Amitinder Kaur
• 金额: $ 19.39万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357924
• 关键词: Acquired Immunodeficiency Syndrome; Alleles; CD8-Positive T-Lymphocytes; Cercocebus atys; Cytotoxic T-Lymphocytes; Evaluation; Funding; Grant; HIV; MHC Class I Genes; National Center for Research Resources; New England; Pathogenesis; Play; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; SIV; Source; Study models; T-Lymphocyte Epitopes; United States National Institutes of Health; Virus Diseases; Virus Replication; base; cost; in vivo

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. MHC class I-restricted cytotoxic T-lymphocytes (CTL) play an important role in controlling human immunodeficiency virus and simian immunodeficiency virus (SIV) infection. As a natural host of SIV, sooty mangabeys (Cercocebus atys; Ceat) are a valuable model for the study of AIDS pathogenesis. We have previously defined several immunodominant SIV-specific CTL epitopes in sooty mangabeys and shown that CD8-positive T lymphocytes inhibit SIV replication in vivo in naturally SIV-infected sooty mangabeys. In order to identify the MHC class I restriction of immunodominant CTL epitopes, we have cloned and characterized MHC class I genes of sooty mangabeys. These studies will facilitate evaluation of the role of CTL in maintaining nonpathogenic SIV infection in sooty mangabeys.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 MHC I类限制的细胞毒性T淋巴细胞（CTL）在控制人免疫缺陷病毒和邻肌免疫缺陷病毒（SIV）感染中起着重要作用。作为SIV的天然寄主，烟熏芒果（Cercocebus atys; Ceat）是研究AIDS发病机理的宝贵模型。我们以前已经定义了烟草芒果中的几个免疫主导的SIV特异性CTL表位，并表明CD8阳性T淋巴细胞抑制了自然SIV感染的烟灰芒果中的体内SIV复制。为了识别MHC I类限制免疫主导CTL表位的限制，我们已经克隆并表征了MHC MHC I类烟草Mangabeys的基因。 这些研究将促进评估CTL在烟雾芒果中维持非对照SIV感染中的作用。