CELLULAR IMMUNE RESPONSES IN SIV-INFECTED SOOTY MANGABEYS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目前正在使用ELISPOT和细胞内细胞因子染色分析以及体内CD8阳性T淋巴细胞耗尽研究，研究SIV特异性细胞免疫反应在维持SIV感染的煤色芒果中的非致病性SIV感染中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The role of SIV-specific cellular immune responses in maintaining nonpathogenic SIV infection in sooty mangabeys is being investigated in SIV-infected sooty mangabeys using Elispot and intracellular cytokine staining assays as well as by in vivo CD8-positive T lymphocyte depletion studies.