CONGENITAL TRANSMISSION OF RHESUS CMV IN RHESUS MACAQUES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 最近的研究表明，在用SIVmac 239多次低剂量直肠攻击后，来自RhCMV载体的SIV抗原的表达刺激保护性免疫应答。将这些发现转化为人类临床试验将在很大程度上取决于证明RhCMV载体被充分减毒以防止载体相关的病理结果。首先，这意味着证明RhCMV载体不能穿过胎盘并先天性感染胎儿。迄今为止，这是不可能的，因为没有任何未感染RhCMV的繁殖年龄猕猴。无特定病原体（SPF）队列现在提供了机会，通过评估载体在非人灵长类动物模型中的安全性，推进关于RhCMV作为疫苗载体的研究结果的转化。因此，这符合父母补助金的意图和精神，增加了SPF动物在艾滋病相关研究中的效用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Recent work has demonstrated that expression of SIV antigens from a RhCMV vector stimulates protective immune responses following multiple low-dose rectal challenge with SIVmac239. Translation of these findings to human clinical trials will depend, in large part, on demonstration that the RhCMV vector is sufficiently attenuated to prevent vector-associated pathological outcomes. Primarily, this means demonstration that the RhCMV vector cannot cross the placenta and congenitally infect the fetus. This has not been possible to date because there have not been any breeding age macaques that are uninfected with RhCMV. The Specific Pathogen Free (SPF) cohort now provides the opportunity to advance the translation of the findings about RhCMV as a vaccine vector by evaluating the safety of the vector in the nonhuman primate model. As such, this meets the intent and spirit of the parent grant by augmenting the utility of the SPF animals for AIDS-related research.