EFF OF FISH OIL AND ALPHA-LIPOIC ACID ON THE PROGR OF INSULIN RESIST

鱼油和硫辛酸对胰岛素抵抗进程的影响

基本信息

  • 批准号:
    8357277
  • 负责人:
  • 金额:
    $ 7.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The prevalence of obesity is increasing markedly. Even moderate obesity can contribute to the development of the pathological characteristics of the Metabolic Syndrome. Insulin resistance is the underlying characteristic of Metabolic Syndrome and, along with beta-cell dysfunction, results in Type 2 Diabetes Mellitus (T2DM). Due to the rising incidence of Metabolic Syndrome and T2DM and the limited ability of current treatments to prevent their long-term complications, it is clear that more attention needs to be focused on primary prevention of insulin resistance. In this application we propose to investigate the long-term (1 year) effects of fish oil and ¿-lipoic acid supplementation, alone and in combination, to prevent or attenuate the progression of insulin resistance and dyslipidemia in a nonhuman primate model of diet-induced insulin resistance. The development of insulin resistance in obese rhesus monkeys shares similar features with the progression of metabolic disease in humans. We have previously demonstrated that providing obese rhesus monkeys with a sugar-sweetened beverage daily in combination with ad libitum access to their normal diet for 1 year results in modest weight and body fat gain accompanied by a rapid progression of insulin resistance and dyslipidemia (elevated triglyceride and reduced HDL levels). The use of this model in which rigorous control and compliance with diet and supplement intake can be ensured will allow us to determine the effects of long-term administration of fish oil and ¿-lipoic acid on the progression of thedevelopment and progression of insulin resistance and dyslipidemia. We propose to determine the efficacy of two widely used nutritional supplements known to activate PPARs and/or target lipid dysregulation, inflammation (fish oil), and oxidative stress (alpha-lipoic acid) in this nonhuman primate model. We will pursue the following specific aims: Specific Aim 1: Test the hypothesis that supplementation with fish oil will activate PPARalpha, gamma and delta, increase plasma adiponectin levels, and prevent or attenuate the progression of insulin resistance. Specific Aim 2: Test the hypothesis that supplementation with the potent anti-oxidant, alpha-lipoic acid will reduce oxidative stress and prevent or attenuate the progression of insulin resistance. Specific Aim 3: Test the hypothesis that the effects fish oil in combination with alpha-lipoic acid will be greater than either fish oil or alpha-lipoic acid alone. In addition, we will determine the effects of the supplements on lipid, oxidative stress and inflammatory parameters associated with insulin resistance and cardiovascular risk including substrate oxidation, apolipoprotein-B, lipoprotein particle size, adiponectin, C-reactive protein, homocysteine, interleukin-6, tumor necrosis factor-alpha, monocyte-chemoattractant protein-1, soluble adhesion factors, and PAI-1.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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PETER J HAVEL其他文献

PETER J HAVEL的其他文献

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{{ truncateString('PETER J HAVEL', 18)}}的其他基金

Adverse metabolic effects of dietary sugar _ Ad libitum vs energy-balanced diets
膳食糖对代谢的不良影响_随意饮食与能量平衡饮食
  • 批准号:
    9067515
  • 财政年份:
    2014
  • 资助金额:
    $ 7.56万
  • 项目类别:
Adverse Metabolic Effects of Dietary Sugar _ Ad Libitum vs Energy-Balanced Diets
膳食糖的不良代谢影响_随意饮食与能量平衡饮食
  • 批准号:
    9102557
  • 财政年份:
    2014
  • 资助金额:
    $ 7.56万
  • 项目类别:
Adverse metabolic effects of dietary sugar _ Ad libitum vs energy-balanced diets
膳食糖对代谢的不良影响_随意饮食与能量平衡饮食
  • 批准号:
    8916824
  • 财政年份:
    2014
  • 资助金额:
    $ 7.56万
  • 项目类别:
Adverse metabolic effects of dietary sugar: Ad libitum vs energy-balanced diets
膳食糖对代谢的不利影响:随意饮食与能量平衡饮食
  • 批准号:
    9283193
  • 财政年份:
    2014
  • 资助金额:
    $ 7.56万
  • 项目类别:
Adverse metabolic effects of dietary sugar _ Ad libitum vs energy-balanced diets
膳食糖对代谢的不良影响_随意饮食与能量平衡饮食
  • 批准号:
    8613141
  • 财政年份:
    2014
  • 资助金额:
    $ 7.56万
  • 项目类别:
MAINTENANCE AND MONITORING OF RHESUS MONKEYS WITH TYPE-2 DIABETES
患有 2 型糖尿病的恒河猴的维护和监测
  • 批准号:
    8357303
  • 财政年份:
    2011
  • 资助金额:
    $ 7.56万
  • 项目类别:
Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia
果糖的脂肪酸来源和 HFCS 诱发的餐后高甘油三酯血症
  • 批准号:
    8487437
  • 财政年份:
    2011
  • 资助金额:
    $ 7.56万
  • 项目类别:
Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia
果糖的脂肪酸来源和 HFCS 诱发的餐后高甘油三酯血症
  • 批准号:
    8680329
  • 财政年份:
    2011
  • 资助金额:
    $ 7.56万
  • 项目类别:
Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia
果糖的脂肪酸来源和 HFCS 诱发的餐后高甘油三酯血症
  • 批准号:
    8215574
  • 财政年份:
    2011
  • 资助金额:
    $ 7.56万
  • 项目类别:
Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia
果糖的脂肪酸来源和 HFCS 诱发的餐后高甘油三酯血症
  • 批准号:
    8321550
  • 财政年份:
    2011
  • 资助金额:
    $ 7.56万
  • 项目类别:

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