OFFSPRING POSTNATAL CARDIOVASCULAR HEALTH

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这项初步研究的目的是确定血清反应是否可以测量（Hb 1Ac和胆固醇），形态测量（体重、局部脂肪分布）和心肾功能（心率、血压、尿量和成分）和分子遗传测量（肝和肾转录组表达）与膳食脂肪，胆固醇，母亲在怀孕期间饮食减少30%（母亲营养减少，MNR），后代中的碳水化合物和盐表明MNR的持续影响，并建议制定血脂异常、高血压和/或糖尿病计划。我们已经显示了对出生后胆固醇水平的影响，我们将调查受影响的系统，为提交R 01的未来NIH R 01资金做准备。该项目的最终目标是利用狒狒胎儿研究和产后研究的信息，制定产后从缺陷胎儿环境中恢复的策略，以最大限度地减少成年人类后代患心血管疾病的风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this pilot study is to determine if response of serum measures (Hb1Ac and cholesterol), morphometric measures (body weight, regional fat distribution) and cardio-renal function (heart rate, blood pressure, urine production and composition) and molecular genetic measures (liver and kidney transcriptome expression) to dietary fat, cholesterol, carbohydrate and salt in offspring of mothers fed a 30% reduced diet during pregnancy (maternal nutrient reduction, MNR) offspring indicate persistent effects of MNR and suggest programming for dyslipidemia, hypertension, and/or diabetes. We have already shown effects on post-natal cholesterol levels and we will investigate the systems impacted in preparation for submission of R01's for future NIH R01 funding. The ultimate goal of this project will be to use information from baboon fetal studies and postnatal studies to develop strategies for recuperation from the deficient fetal environment postnatally to minimize risk of cardiovascular disease in the adult human offspring.