LIPOPROTEIN AND HYPERTENSION QTL CANDIDATE GENES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 项目3的目标是在狒狒模型中鉴定影响与血脂异常、氧化损伤和高血压相关的定量表型的基因。我们目前正在研究内皮脂肪酶的变化影响高密度脂蛋白胆固醇（HDLC）变化的分子机制。我们已经确定了内皮脂肪酶基因启动子的功能变异，影响HDLC。此外，我们已经确定了转录因子的差异结合这些功能的变体之一，并定量表达的转录因子在狒狒的肝脏，表现出低和高HDLC狒狒之间的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of Project 3 is to identify genes that influence quantitative phenotypes related to dyslipidemia, oxidative damage and hypertension in the baboon model. We are currently studying molecular mechanisms by which variation in endothelial lipase influences variation in high density lipoprotein cholesterol (HDLC). We have identified functional variants in the endothelial lipase gene promoter that influence HDLC. In addition, we have identified transcription factors that differentially bind to one of these functional variants and quantified expression of the transcription factors in baboon liver, demonstrating differences between low and high HDLC baboons.