权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Comparative Genomics and Bioinformatics Core

比较基因组学和生物信息学核心

基本信息

批准号：
10309096
负责人：
Laura A Cox
金额：
$ 7.59万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10309096
关键词：
ATAC-seq Affect Agreement Archives Binding Bioinformatics Chromatin Data Databases Deposition Diagnosis Diagnostic Disease Endometrial Stromal Cell Endometrium Ensure Epithelial Cells Foundations Functional disorder Genes Genetic Transcription Genomics Goals Human Individual Infertility Laboratories Lesion Literature Macaca mulatta Marsupialia Methodology Modeling Molecular Molecular Analysis Monkeys Mus Pathway Analysis Pathway interactions Peritoneal Fluid Phase Plasma Practice Management Process Publishing Research Personnel Rhesus Rodent Role SIRT1 gene Sampling Therapeutic Tissue Sample Tissues United States National Institutes of Health Woman comparative genomics data management data sharing data warehouse endometriosis epigenome epigenomics genetically modified cells genome-wide improved innovation metabolome metabolomics nonhuman primate nuclease phenotypic data precision medicine success tool transcriptome transcriptome sequencing transcriptomics

项目摘要

Comparative Genomics And Bioinformatics Core SUMMARY/ABSTRACT The Comparative Genomics and Bioinformatics (CGB) Core will provide state-of-the-art comparative genomic and bioinformatic analyses, and data warehousing to support the overarching goal of the P01 to improve our understanding of endometriosis disease pathophysiology in women and provide a foundation for improving treatment. The scientific premise that evolutionarily conserved genomic features inform function is well- established. An innovative aspect of the Core is the use of comparative genomics in humans, monkeys and mice, including transcriptomics and epigenomics, to identify evolutionarily conserved pathways central to endometriosis pathophysiology. The CGB Core has 4 Specific Aims to support the overall goals of the P01: 1) Identify transcriptional pathways and networks associated with disease status in women (Projects 1&2), mice (Project 2), and rhesus macaques (Project 3); 2) Integrate transcriptome data with epigenome (chromatin) and metabolome data generated in the Projects to prioritize pathways and causal networks most likely to have regulatory roles in disease status; 3) Identify disease-associated genes, pathways, and causal networks that are conserved among the three species; and 4) Provide a data warehouse for organizing and sharing data generated in the CGB Core and the Projects, and comply with NIH data sharing requirements. The Core Leader Dr. Cox has extensive comparative genomic expertise that includes studies with marsupials, rodents, nonhuman primates, and humans. All methodologies, analysis tools, and data management practices proposed for the Core are routinely used and well-established in the Core Leader’s laboratory, supporting success of the CGB Core to achieve these aims. Successful completion of these aims will reveal molecular pathways and networks associated with disease status for each species and, by identifying those conserved among humans, mice and rhesus, will nominate regulators that are central to the disease process. Achieving these goals will contribute to a better understanding of the disease process which will inform diagnosis and treatment for long-lasting improvement in the lives of women suffering from endometriosis.

比较基因组学和生物信息学核心