MOSAIC VACCINE-ELICITED IMMUNE RESPONSES IN RHESUS MONKEYS

马赛克疫苗在恒河猴中引起的免疫反应

• 批准号: 8357984
• 负责人: NORMAN L LETVIN
• 金额: $ 6.84万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357984
• 关键词: Antigens; CD8-Positive T-Lymphocytes; Cellular Immunity; Consensus; Development; Funding; Genes; Genetic Heterogeneity; Genetic Variation; Grant; HIV; HIV vaccine; Immune response; Macaca mulatta; National Center for Research Resources; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Solutions; Source; United States National Institutes of Health; Vaccination; Vaccines; Virus; base; cost; design; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Creation of a successful HIV vaccine will require development of an immunogen that will generate cellular immunity with sufficient cross-clade breadth to deal with the extreme genetic diversity of the virus. Recently it has been suggested that vaccines based on centralized HIV gene sequences might provide a solution to the problem posed by the genetic heterogeneity of the circulating strains of HIV. Both consensus and polyvalent mosaic immunogens are based on centralized gene sequences. The present study was designed to explore the breadth of CD4+ and CD8+ T lymphocyte responses generated by vaccination with polyvalent mosaic as compared to vaccination with consensus immunogens.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 创造一种成功的艾滋病毒疫苗将需要开发一种免疫原，这种免疫原将产生足够广泛的细胞免疫，以应对病毒的极端遗传多样性。最近，有人建议，基于集中的艾滋病毒基因序列的疫苗可能为艾滋病毒流行毒株的遗传异质性带来的问题提供解决方案。共识和多价马赛克免疫原都是基于集中的基因序列。本研究旨在探索多价马赛克疫苗与普通免疫原疫苗所产生的CD4+和CD8+T淋巴细胞反应的广度。