RNA EXPRESSION PROFILES OF SIV-SPECIFIC CD8+ T CELLS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 已知感染SIV的Mamu-A*01+恒河猴的血浆病毒载量低于Mamu-A*01-猕猴。CD8+T细胞可能在病毒血症的控制中发挥作用。为了验证这一假设，分离了MAMU-A*01+(A*02-，B*17-，B*08-)猴和MAMU-A*02+(A*01-，B*17-，B*08-)猴的SIV特异性CD8+T细胞。MAMU-A*01+猴子的病毒特异性CD8+T细胞可能与MAMU-A*02+猴子的不同。这种差异可能反映在不同基因型猴的病毒特异性CD8+T细胞中存在的RNA转录本中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. It is known that SIV-infected Mamu-A*01+ rhesus macaques develop lower plasma viral loads than Mamu-A*01- monkeys. CD8+ T cells possibly play a role in the control of viremia. To test this hypothesis SIV-specific CD8+ T cells from Mamu-A*01+ (A*02-, B*17-,B*08-) monkeys and Mamu-A*02+ (A*01-, B*17-, B*08-) monkeys are being isolated. Virus-specific CD8+ T cells may be different in Mamu-A*01+ monkeys from those on Mamu-A*02+ monkeys. This difference may be reflected in the RNA transcripts that are present in the virus-specific CD8+ T cells from monkeys with different genotypes.