Significance of CD8-positive T lymphocytes in graft and recipient peripheral blood in the immunoresponse after allogeneic cord blood transplantation

点击翻译按钮获取中文摘要

We analyzed a significance of CD8-positive T lymphocytes in graft and recipient peripheral blood in the immunoresponse after allogeneic hematopoietic stem cell transplantation. We observed the followings : (1) recovery of nalve CD8-positive T lymphocytes after cord blood transplantation is comparable to that after bone marrow transplantation, (2) CD8-positive T lymphocytes that survive beyond pre-transplant conditioning can cause graft rejection, and (3) under immunological pressure by CD8-positive T lymphocytes that recognize mismatched HLA molecule between donor and recipient, residual leukemia blast clones whose HLA expression is low can expand and result in relapse.