Significance of CD8-positive T lymphocytes in graft and recipient peripheral blood in the immunoresponse after allogeneic cord blood transplantation

移植者和受者外周血CD8阳性T淋巴细胞在同种异体脐带血移植后免疫反应中的意义

• 批准号: 20591149
• 负责人: MURATA Makoto
• 金额: $ 2.91万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591149/
• 关键词: 臍帯血移植; 骨髄移植; 生着; 拒絶; 移植片対宿主病; 移植片対白血病効果; T細胞; HLA; CD8; CD4

We analyzed a significance of CD8-positive T lymphocytes in graft and recipient peripheral blood in the immunoresponse after allogeneic hematopoietic stem cell transplantation. We observed the followings : (1) recovery of nalve CD8-positive T lymphocytes after cord blood transplantation is comparable to that after bone marrow transplantation, (2) CD8-positive T lymphocytes that survive beyond pre-transplant conditioning can cause graft rejection, and (3) under immunological pressure by CD8-positive T lymphocytes that recognize mismatched HLA molecule between donor and recipient, residual leukemia blast clones whose HLA expression is low can expand and result in relapse.

我们分析了移植物和受体外周血中CD8+T淋巴细胞在异基因造血干细胞移植后免疫反应中的意义。我们观察到：(1)脐血移植后CD8+T淋巴细胞的恢复与骨髓移植后相当，(2)CD8+T淋巴细胞存活超过移植前条件可引起移植物排斥反应，(3)CD8+T淋巴细胞在免疫压力下识别供受者之间不匹配的HLA分子，低表达的残留白血病原始克隆可扩大并导致复发。

项目成果

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Clinical characteristics of chronic graft-versus-host disease following umbilical cord blood transplantation for adults

成人脐带血移植后慢性移植物抗宿主病的临床特征

• 发表时间: 2008
• 期刊: Bone Marrow Transplantation 41
• 作者: Sugimoto K;et al.
• 通讯作者: et al.

Characterization of Cytotoxic T Lymphocyte Clones Isolated from Bone Marrow Transplant Recipient with HLA-Cw-Mismatched Donor

从 HLA-Cw 不匹配供体骨髓移植受者分离的细胞毒性 T 淋巴细胞克隆的表征

• 发表时间: 2008
• 作者: Sugimoto K;et al.
• 通讯作者: et al.

Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy

• DOI: 10.1007/s12185-008-0221-1
• 发表时间: 2008-12-01
• 期刊: INTERNATIONAL JOURNAL OF HEMATOLOGY
• 影响因子: 2.1
• 作者: Abe, Akihiro;Minami, Yosuke;Naoe, Tomoki
• 通讯作者: Naoe, Tomoki

Retension but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy

伊马替尼治疗后慢性粒细胞白血病造血干细胞中 BCR-ABL 转录物保留但显着减少

• 发表时间: 2008
• 期刊: International Journal of Hematology 88
• 作者: Abe A;et al.
• 通讯作者: et al.