CELLULAR, MOLECULAR, HISTOPHATOL, AND PHYSIOL CHAR OF A MACAQUE MODEL OF COPD

COPD 猕猴模型的细胞、分子、组织磷脂和生理学特征

• 批准号: 8357346
• 负责人: DALLAS Melvin HYDE
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357346
• 关键词: Biological Markers; California; Chronic Obstructive Airway Disease; Development; Drug Delivery Systems; Funding; Grant; Macaca; Macaca mulatta; Modeling; Molecular; Monkeys; National Center for Research Resources; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Respiratory Tract Infections; Source; Techniques; Time; Tissues; United States National Institutes of Health; Validation; Vascular Endothelial Growth Factors; clinically relevant; cost; human disease; inhibitor/antagonist; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The main aim of the study is to develop a rhesus monkey COPD model of human disease by treating two groups of monkeys: one group is exposed to DCS and a VEGF inhibitor, and the other group is exposed to clinically relevant levels of DCS and a respiratory infection. Treated COPD monkeys are compared to healthy controls. The above study should permit: 1. Characterization of the induction and subsequent development over time of the COPD response in rhesus monkeys. 2. Use of using cellular, molecular, and histopathological techniques, to confirm previous findings in human disease tissues (validation of model), as well as identify biomarkers and/or drug targets not previously associated with COPD.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该研究的主要目的是通过治疗两组猴子来开发人类疾病的恒河猴COPD模型：一组暴露于DC和VEGF抑制剂，另一组暴露于临床上相关的DC和呼吸道感染水平。 将经过处理的COPD猴子与健康对照组进行了比较。 上述研究应允许： 1。恒河猴COPD反应的诱导和随后发展的表征。 2。使用使用细胞，分子和组织病理学技术来确认人类疾病组织中的先前发现（模型的验证），以及鉴定以前与COPD相关的生物标志物和/或药物靶标。