CELLULAR, MOLECULAR, HISTOPHATOL, AND PHYSIOL CHAR OF A MACAQUE MODEL OF COPD
COPD 猕猴模型的细胞、分子、组织磷脂和生理学特征
基本信息
- 批准号:8357346
- 负责人:
- 金额:$ 5.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-05-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:Biological MarkersCaliforniaChronic Obstructive Airway DiseaseDevelopmentDrug Delivery SystemsFundingGrantMacacaMacaca mulattaModelingMolecularMonkeysNational Center for Research ResourcesPrimatesPrincipal InvestigatorResearchResearch InfrastructureResourcesRespiratory Tract InfectionsSourceTechniquesTimeTissuesUnited States National Institutes of HealthValidationVascular Endothelial Growth Factorsclinically relevantcosthuman diseaseinhibitor/antagonistresponse
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
The main aim of the study is to develop a rhesus monkey COPD model of human disease by treating two groups of monkeys: one group is exposed to DCS and a VEGF inhibitor, and the other group is exposed to clinically relevant levels of DCS and a respiratory infection. Treated COPD monkeys are compared to healthy controls.
The above study should permit:
1. Characterization of the induction and subsequent development over time of the COPD response in rhesus monkeys.
2. Use of using cellular, molecular, and histopathological techniques, to confirm previous findings in human disease tissues (validation of model), as well as identify biomarkers and/or drug targets not previously associated with COPD.
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DALLAS Melvin HYDE其他文献
DALLAS Melvin HYDE的其他文献
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{{ truncateString('DALLAS Melvin HYDE', 18)}}的其他基金
IMMUNE RESP IN NEONATAL HOUSE DUST MITE-SENSITIZED MONKEYS FOL EXPTO OZONE
新生屋尘螨敏感猴对臭氧的免疫反应
- 批准号:
8357240 - 财政年份:2011
- 资助金额:
$ 5.04万 - 项目类别:
GLUTATHIONE LEVELS IN AIRWAYS OF INFANT MONKEYS EXP TO O3 WITH & WITHOUT HDMA
幼猴气道中的谷胱甘肽水平 EXP 至 O3
- 批准号:
8357246 - 财政年份:2011
- 资助金额:
$ 5.04万 - 项目类别:
AFFERENT NERVE ACTIV IN ISOL TRACHEA OF INF MONKEYS EXP TO OZONE & ALLERGEN
INF猴隔离气管暴露于臭氧的传入神经活动
- 批准号:
8357239 - 财政年份:2011
- 资助金额:
$ 5.04万 - 项目类别:
POSTNATAL REMODELING IN DIST AIRWAY OF INFANT MONKEYS EXP TO OZONE & ALLERGEN
暴露于臭氧的幼猴的产后呼吸道重塑
- 批准号:
8357245 - 财政年份:2011
- 资助金额:
$ 5.04万 - 项目类别:
AFFERENT NERVE ACTIV IN ISOL TRACHEA OF INF MONKEYS EXP TO OZONE & ALLERGEN
INF猴隔离气管暴露于臭氧的传入神经活动
- 批准号:
8172506 - 财政年份:2010
- 资助金额:
$ 5.04万 - 项目类别:
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