INHALATION EXPOSURE FACILITY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 位于CNPRC的吸入接触设施是大学校园中最大的设施之一。 它允许使用非人灵长类动物进行独特的人类健康相关肺部研究的机会。 有能力在体内或体外暴露于精确表征和控制的气体和气溶胶气氛。 就空气污染对健康的影响研究而言，用于接触研究的试验对象范围可包括动物、分离和灌注的肺、气管外植体和人或猴肺细胞培养物。 这允许一个综合的，比较的方法来定义呼吸系统损伤和修复的机制。 肺功能实验室提供了一个全面的测试从婴儿到成年非人灵长类动物。 提供的服务： + 特殊暴露 + 臭氧生成和监测 + 气溶胶生成和分析 + 氮氧化物生成和监测 + 过敏原的产生和分析 + 过滤空气暴露 + ETS生成和分析 肺功能检测实验室 + 基线气道阻力测试 + 气道反应性测试 + 过敏原反应性试验 + 静态肺力学测试 + 晚期过敏原反应性试验 + 肺弥散量、心输出量和肺毛细血管容积 该设施继续提供稳定的、充分表征的暴露于空气污染物、过敏原、治疗剂、气溶胶和研究项目所需的其他测试气氛的暴露。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Inhalation Exposure Facility located at the CNPRC is one of the largest in existence on a university campus. It permits unique human health-related pulmonary research opportunities using nonhuman primates. Capabilities exist for in vivo or in vitro exposure to precisely characterized and controlled atmospheres of gases and aerosols. For health effects of air pollution research, the range of test subjects used for exposure studies can include animals, isolated and perfused lungs, tracheal explants and human or monkey lung cell cultures. This permits an integrated, comparative approach to defining mechanisms of respiratory system injury and repair. The pulmonary function laboratory offers a comprehensive array of testing for infant through adult nonhuman primates. Services Offered: + Special Exposures + Ozone Generation and Monitoring + Aerosol Generation and Analysis + NOx Generation and Monitoring + Allergen Generation and Analysis + Filtered Air Exposure + ETS Generation and Analysis Pulmonary Function Testing Laboratory + Baseline Airway Resistance Testing + Airway Responsiveness Testing + Allergen Responsiveness Testing + Static Lung Mechanics Testing + Late Phase Allergen Responsiveness Testing + Lung diffusing capacity, cardiac output and pulmonary capillary volume This facility continued to provide stable, well characterized exposures to air pollutants, allergens, therapeutic agents, aerosols and other test atmospheres as required by the research projects.