INHALATION EXPOSURE FACILITY
吸入暴露设施
基本信息
- 批准号:8357253
- 负责人:
- 金额:$ 5.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-05-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAerosolsAir PollutionAirway ResistanceAllergensAnimalsBlood capillariesCaliforniaCardiac OutputCell Culture TechniquesDiffuseExposure toFundingGasesGenerationsGrantHealthHumanIn VitroInfantInhalation ExposureLaboratoriesLungMechanicsMonitorMonkeysNational Center for Research ResourcesPhasePrimatesPrincipal InvestigatorPulmonary function testsResearchResearch InfrastructureResourcesRespiratory SystemServicesSourceTestingUnited States National Institutes of HealthUniversitiesair filtercapillarycomparativecostin vivoinjury and repairnonhuman primateozone exposureplanetary Atmospherepulmonary function
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
The Inhalation Exposure Facility located at the CNPRC is one of the largest in existence on a university campus. It permits unique human health-related pulmonary research opportunities using nonhuman primates. Capabilities exist for in vivo or in vitro exposure to precisely characterized and controlled atmospheres of gases and aerosols. For health effects of air pollution research, the range of test subjects used for exposure studies can include animals, isolated and perfused lungs, tracheal explants and human or monkey lung cell cultures. This permits an integrated, comparative approach to defining mechanisms of respiratory system injury and repair. The pulmonary function laboratory offers a comprehensive array of testing for infant through adult nonhuman primates.Services Offered:
+ Special Exposures
+ Ozone Generation and Monitoring
+ Aerosol Generation and Analysis
+ NOx Generation and Monitoring
+ Allergen Generation and Analysis
+ Filtered Air Exposure
+ DCS Generation and Analysis
Pulmonary Function Testing Laboratory
+ Baseline Airway Resistance Testing
+ Airway Responsiveness Testing
+ Allergen Responsiveness Testing
+ Static Lung Mechanics Testing
+ Late Phase Allergen Responsiveness Testing
+ Lung diffusing capacity, cardiac output and pulmonary capillary volume
这个子项目是利用资源的许多研究子项目之一。
由NIH/NCRR资助的中心拨款提供。对子项目的主要支持
子项目的首席调查员可能是由其他来源提供的,
包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能
表示该子项目使用的中心基础设施的估计数量,
不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。
位于中国人民大学的吸入暴露设施是现有的大学校园中最大的设施之一。它允许使用非人类灵长类动物进行与人类健康相关的独特肺部研究机会。有能力在体内或体外暴露于精确表征和控制的气体和气雾剂大气中。对于空气污染研究对健康的影响,用于暴露研究的测试对象范围可以包括动物、分离和灌流的肺、气管外植体以及人或猴子的肺细胞培养。这使得可以采用综合的、比较的方法来确定呼吸系统损伤和修复的机制。肺功能实验室通过成人非人类灵长类动物为婴儿提供全面的检测。服务提供:
+特别曝光
+臭氧产生和监测
+气溶胶产生和分析
+NOx的产生和监测
+过敏原产生和分析
+过滤空气暴露量
+集散控制系统生成和分析
肺功能检测实验室
+基准气道阻力测试
+航空公司响应性测试
+过敏原反应性测试
+静态肺力学测试
+后期变应原反应性测试
+肺弥散量、心输出量和肺毛细血管容量
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('DALLAS Melvin HYDE', 18)}}的其他基金
IMMUNE RESP IN NEONATAL HOUSE DUST MITE-SENSITIZED MONKEYS FOL EXPTO OZONE
新生屋尘螨敏感猴对臭氧的免疫反应
- 批准号:
8357240 - 财政年份:2011
- 资助金额:
$ 5.04万 - 项目类别:
GLUTATHIONE LEVELS IN AIRWAYS OF INFANT MONKEYS EXP TO O3 WITH & WITHOUT HDMA
幼猴气道中的谷胱甘肽水平 EXP 至 O3
- 批准号:
8357246 - 财政年份:2011
- 资助金额:
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CELLULAR, MOLECULAR, HISTOPHATOL, AND PHYSIOL CHAR OF A MACAQUE MODEL OF COPD
COPD 猕猴模型的细胞、分子、组织磷脂和生理学特征
- 批准号:
8357346 - 财政年份:2011
- 资助金额:
$ 5.04万 - 项目类别:
AFFERENT NERVE ACTIV IN ISOL TRACHEA OF INF MONKEYS EXP TO OZONE & ALLERGEN
INF猴隔离气管暴露于臭氧的传入神经活动
- 批准号:
8357239 - 财政年份:2011
- 资助金额:
$ 5.04万 - 项目类别:
POSTNATAL REMODELING IN DIST AIRWAY OF INFANT MONKEYS EXP TO OZONE & ALLERGEN
暴露于臭氧的幼猴的产后呼吸道重塑
- 批准号:
8357245 - 财政年份:2011
- 资助金额:
$ 5.04万 - 项目类别:
AFFERENT NERVE ACTIV IN ISOL TRACHEA OF INF MONKEYS EXP TO OZONE & ALLERGEN
INF猴隔离气管暴露于臭氧的传入神经活动
- 批准号:
8172506 - 财政年份:2010
- 资助金额:
$ 5.04万 - 项目类别:
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