INHALATION EXPOSURE FACILITY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 位于中国人民大学的吸入暴露设施是现有的大学校园中最大的设施之一。它允许使用非人类灵长类动物进行与人类健康相关的独特肺部研究机会。有能力在体内或体外暴露于精确表征和控制的气体和气雾剂大气中。对于空气污染研究对健康的影响，用于暴露研究的测试对象范围可以包括动物、分离和灌流的肺、气管外植体以及人或猴子的肺细胞培养。这使得可以采用综合的、比较的方法来确定呼吸系统损伤和修复的机制。肺功能实验室通过成人非人类灵长类动物为婴儿提供全面的检测。服务提供： 特殊曝光 臭氧的产生和监测 气溶胶的产生和分析 氮氧化物的产生与监测 过敏原的产生和分析 过滤后的空气暴露 集散控制系统的生成与分析 肺功能检测实验室 基线呼吸道阻力试验 呼吸道反应性试验 过敏原反应性试验 静态肺力学测试 晚期变应原反应性试验 肺弥散量、心输出量和肺毛细血管容量

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Inhalation Exposure Facility located at the CNPRC is one of the largest in existence on a university campus. It permits unique human health-related pulmonary research opportunities using nonhuman primates. Capabilities exist for in vivo or in vitro exposure to precisely characterized and controlled atmospheres of gases and aerosols. For health effects of air pollution research, the range of test subjects used for exposure studies can include animals, isolated and perfused lungs, tracheal explants and human or monkey lung cell cultures. This permits an integrated, comparative approach to defining mechanisms of respiratory system injury and repair. The pulmonary function laboratory offers a comprehensive array of testing for infant through adult nonhuman primates.Services Offered: + Special Exposures + Ozone Generation and Monitoring + Aerosol Generation and Analysis + NOx Generation and Monitoring + Allergen Generation and Analysis + Filtered Air Exposure + DCS Generation and Analysis Pulmonary Function Testing Laboratory + Baseline Airway Resistance Testing + Airway Responsiveness Testing + Allergen Responsiveness Testing + Static Lung Mechanics Testing + Late Phase Allergen Responsiveness Testing + Lung diffusing capacity, cardiac output and pulmonary capillary volume