INHALATION EXPOSURE FACILITY

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 位于CNPRC的吸入接触设施是大学校园中最大的设施之一。 它允许使用非人灵长类动物进行独特的人类健康相关肺部研究的机会。 有能力在体内或体外暴露于精确表征和控制的气体和气溶胶气氛。 就空气污染对健康的影响研究而言，用于接触研究的试验对象范围可包括动物、分离和灌注的肺、气管外植体和人或猴肺细胞培养物。 这允许一个综合的，比较的方法来定义呼吸系统损伤和修复的机制。 肺功能实验室为从婴儿到成年非人灵长类动物提供全面的测试。 + 特殊暴露 + 臭氧生成和监测 + 气溶胶生成和分析 + 氮氧化物生成和监测 + 过敏原的产生和分析 + 过滤空气暴露 + DCS生成与分析 肺功能检测实验室 + 基线气道阻力测试 + 气道反应性测试 + 过敏原反应性试验 + 静态肺力学测试 + 晚期过敏原反应性试验 + 肺弥散量、心输出量和肺毛细血管容积

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Inhalation Exposure Facility located at the CNPRC is one of the largest in existence on a university campus. It permits unique human health-related pulmonary research opportunities using nonhuman primates. Capabilities exist for in vivo or in vitro exposure to precisely characterized and controlled atmospheres of gases and aerosols. For health effects of air pollution research, the range of test subjects used for exposure studies can include animals, isolated and perfused lungs, tracheal explants and human or monkey lung cell cultures. This permits an integrated, comparative approach to defining mechanisms of respiratory system injury and repair. The pulmonary function laboratory offers a comprehensive array of testing for infant through adult nonhuman primates.Services Offered: + Special Exposures + Ozone Generation and Monitoring + Aerosol Generation and Analysis + NOx Generation and Monitoring + Allergen Generation and Analysis + Filtered Air Exposure + DCS Generation and Analysis Pulmonary Function Testing Laboratory + Baseline Airway Resistance Testing + Airway Responsiveness Testing + Allergen Responsiveness Testing + Static Lung Mechanics Testing + Late Phase Allergen Responsiveness Testing + Lung diffusing capacity, cardiac output and pulmonary capillary volume