ELASTOMERIC POLYMERS & TUNABLE BIOLOGICAL FUNCTIONS FOR VOCAL FOLD TISSUE ENG
弹性聚合物
基本信息
- 批准号:8360585
- 负责人:
- 金额:$ 31.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-08-01 至 2012-07-31
- 项目状态:已结题
- 来源:
- 关键词:AdhesivesAirAmino AcidsArchitectureBiochemicalBiocompatible MaterialsBiologicalBiological FactorsBiological ProcessCaringCell ProliferationCellsCenters of Research ExcellenceCharacteristicsChemicalsClinicalCuesDevicesDiseaseElasticityElastinElastomersEngineeringExhibitsExtracellular MatrixFacultyFrequenciesFundingGrantHeparin BindingHybridsLamina PropriaMatrix MetalloproteinasesMechanical StimulationMechanical StressMechanicsMethodsMolecularNational Center for Research ResourcesNatural regenerationNatureOrganic ChemistryPediatric HospitalsPeptide SynthesisPeptidesPolymer ChemistryPolymersPrincipal InvestigatorProductionPropertyProteinsResearchResearch InfrastructureResourcesRouteRubberSourceStreamStructureSystemTertiary Protein StructureTissue EngineeringTissuesUnited States National Institutes of Healthangiogenesisbasecareercostcrosslinkdesignelastomericmimeticsnovelpolypeptideresilienceresilinscaffoldsolid statesoundvocal cord
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
One of the most remarkable mechanical devices that Nature has engineered consists of two small folds
of tissue called vocal folds, which are responsible for the production of a great variety of sounds when
vibrated by the tracheal air-stream. Under normal conditions, vocal folds can sustain up to 30% strain at
frequencies of 100 to 1000 Hz. However, excessive mechanical stresses and deleterious pathological
conditions can cause damage to this delicate system, resulting in a wide spectrum of vocal fold disorders. To
date, optimal treatment for vocal fold disorders has not yet been realized, and tissue engineering methods
hold promise for the regeneration of functional vocal folds. However, the unique biochemical composition,
structural organization, and viscoelastic properties of vocal folds have significantly complicated tissue
engineering efforts that utilize traditional polymeric biomaterials.
In this new collaborative effort that integrates the unique expertise of junior and early-career faculty, we
will produce novel bioactive elastomers that can be used as conducive scaffolds for vocal fold tissue
engineering. These biomaterials will capture the molecular architecture and mechanical characteristics of
natural elastic proteins (elastin and resilin); given the different physicochemical properties of these two
proteins, employing both will offer a comprehensive approach for tuning morphological, mechanical and
biological properties in the new materials. The elastin mimetic hybrid polymers (EMHP) will comprise a
multiblock structure with alternating hydrophobic, elastic synthetic domains and hydrophilic, peptide-based
cross-linking domains. The synthetic blocks are expected to show rubber-like elasticity that will functionally
mimic the properties of the elastic domains of elastin, while the peptide domains will serve both structural
and biological function. In addition, resilin-based modular polypeptides (RBMP) will be produced with
multiple repeats of unique functional modules including resilin-based peptide domains, heparin-binding
peptides, cell-adhesive peptides, and MMP-sensitive domains in order to produce materials that present
useful biological cues while exhibiting high resilience at high frequencies. Our synthetic strategies will exploit
the established versatility of synthetic polymer chemistry and solid state peptide synthesis, as well as new
orthogonal organic chemistry developed in this COBRE proposal. Chemical methods employing both natural
and non-natural amino acids will be used to crosslink EMHP and RBMP to systematically match mechanical
properties to those of the natural vocal fold lamina propria. With the aid of clinical collaborators at Christiana
Care and the A.I. duPont Hospital for Children, the bioactive elastomers will be evaluated for their ability to
promote vocal fold cell proliferation, angiogenesis, and ECM production. These new materials and
approaches offer promising routes to ultimately engineering functional vocal fold lamina propria via a
combination of viable cells, elastic scaffolds, biological factors and mechanical stimulation.
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Xinqiao Jia', 18)}}的其他基金
Bottom-Up Assembly of Functional Salivary Gland Tissues
功能性唾液腺组织的自下而上组装
- 批准号:
10400243 - 财政年份:2021
- 资助金额:
$ 31.05万 - 项目类别:
Bottom-Up Assembly of Functional Salivary Gland Tissues
功能性唾液腺组织的自下而上组装
- 批准号:
10546502 - 财政年份:2021
- 资助金额:
$ 31.05万 - 项目类别:
A Hydrogel-Based Cellular Model of the Human Vocal Fold
基于水凝胶的人类声带细胞模型
- 批准号:
9028226 - 财政年份:2015
- 资助金额:
$ 31.05万 - 项目类别:
A Hydrogel-Based Cellular Model of the Human Vocal Fold
基于水凝胶的人类声带细胞模型
- 批准号:
10604269 - 财政年份:2015
- 资助金额:
$ 31.05万 - 项目类别:
A Hydrogel-Based Cellular Model of the Human Vocal Fold
基于水凝胶的人类声带细胞模型
- 批准号:
10209183 - 财政年份:2015
- 资助金额:
$ 31.05万 - 项目类别:
A Hydrogel-Based Cellular Model of the Human Vocal Fold
基于水凝胶的人类声带细胞模型
- 批准号:
10394924 - 财政年份:2015
- 资助金额:
$ 31.05万 - 项目类别:
A Hydrogel-Based Cellular Model of the Human Vocal Fold
基于水凝胶的人类声带细胞模型
- 批准号:
9193072 - 财政年份:2015
- 资助金额:
$ 31.05万 - 项目类别:
ELASTOMERIC POLYMERS & TUNABLE BIOLOGICAL FUNCTIONS FOR VOCAL FOLD TISSUE ENG
弹性聚合物
- 批准号:
8168491 - 财政年份:2010
- 资助金额:
$ 31.05万 - 项目类别:
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