BIO2010

生物2010

• 批准号: 8359645
• 负责人: Rheal A Towner
• 金额: $ 10.28万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359645
• 关键词: Academy; Affinity; Biochemistry; Bioinformatics; Biology; Biomedical Research; Biophysical Process; Calendar; Cellular biology; Charge; Chemistry; Contrast Media; Core Facility; Data; Data Set; Databases; Diagnosis; Discipline; District of Columbia; Drug Kinetics; Education; Educational Curriculum; Educational process of instructing; Evolution; Funding; Genes; Genetic; Goals; Grant; Image; Image Analysis; Immunology; Institution; Internet; Magnetic Resonance Imaging; Mathematics; Medical; Metabolic; Microbiology; Modeling; Molecular; Molecular Biology; Molecular Probes; National Center for Research Resources; National Research Council; Oklahoma; Organism; Pathologic Processes; Perfusion; Phylogenetic Analysis; Phylogeny; Physics; Principal Investigator; Process; Protons; Reliance; Reporting; Research; Research Infrastructure; Resources; Roentgen Rays; Science; Sequence Alignment; Sequence Analysis; Signal Transduction; Source; Students; Synthesis Chemistry; Trees; United States National Academy of Sciences; United States National Institutes of Health; X-Ray Computed Tomography; bioimaging; computer program; computer science; cost; expectation; mathematical algorithm; molecular imaging; multidisciplinary; programs; uptake; water diffusion

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. OK-INBRE undergraduate partner institutions is now charged with considering how to "reinvent" Oklahoma's undergraduate science curriculum along the lines of the Bio2010 model (Bio2010: Transforming Undergraduate Education for Future Research Biologists, by the National Research Council of the National Academies, 2003; National Academies of Science, Washington, DC). It is our expectation that these curriculum changes will be implemented incrementally during the next round of OK-INBRE funding. To begin this new type of multidisciplinary teaching, in the next funding period, we propose to provide to PUI students two different week-long course modules developed by the Bioinformatics and accessory MRI Core facility directors. Briefly, the course provided by Dr. Dyer and the Bioinformatics Core has the goal of introducing the students to phylogenetic analyses using free bioinformatics resources available from the web. The students will be exposed to the principles of evolution, sequence databases, sequence comparisons and analyses, sequence similarity searching, multiple sequence alignments, and phylogenetic tree building. Towards the end of this module, the students should understand the applications of bioinformatics resources towards elucidating important and relevant evolutionary information from a sequence dataset. The module will focus on using phylogenetics to make functional assignments, identify homologous relationships between genes, and construct phylogenies between organisms. This course will be taught in upper division molecular biology, genetics, microbiology, or evolution courses and will bridge the disciplines of biology, chemistry, mathematics and computer science. The module will be offered twice in the academic calendar year at various PUIs, as well as during the summer research program on the OUHSC campus. The other multidisciplinary course to be offered to the OK-INBRE PUIs will be taught by Dr. Towner from the accessory MRI core facility located at the OMRF. Biomedical imaging incorporates multiple disciplines. Physics and chemistry are used to understand at the atomic level how protons in MRI and X-rays in CT scans can generate the signals used to generate anatomical images that can be applied for medical diagnosis. Image display and processing involves the use of mathematical algorithms, such as Fourier Transformation in MRI. Biophysical processes, such as selective contrast agent uptake, water diffusion and perfusion, involve combined biology, physics and chemistry concepts. The extension of MRI to obtain metabolic information associated with pathological processes involves a strong reliance on chemistry and biochemistry. Molecular imaging incorporates a molecular-specific affinity component as well as a reporting or signaling component and draws molecular biology (immunology, cell biology) and chemistry (synthesis of molecular probes, pharmacokinetics). Imaging analysis involves the use of mathematical and computer programming for post-processing and quantitative assessment of morphological, molecular, functional and metabolic information that can be obtained from the data. This Bio2010 module will be targeted towards upper division undergraduate students in biochemistry, chemistry, immunology, cell biology, and physics. The module will be offered twice in the academic calendar year, as well as during the summer research program at the OMRF (see Appendix for detailed outlines and syllabi for both of these new Bio2010 multidisciplinary module courses).

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 OK-INBRE 本科合作机构现在负责考虑如何按照 Bio2010 模式“重塑”俄克拉荷马州的本科科学课程（Bio2010：为未来研究生物学家转变本科教育，美国国家科学院国家研究委员会，2003 年；美国国家科学院，华盛顿特区）。 我们期望这些课程变化将在下一轮 OK-INBRE 资助期间逐步实施。 为了开始这种新型的多学科教学，在下一个资助期内，我们建议向 PUI 学生提供两个不同的为期一周的课程模块，这些模块由生物信息学和辅助 MRI 核心设施主管开发。 简而言之，戴尔博士和生物信息学核心提供的课程的目标是向学生介绍使用网络上提供的免费生物信息学资源进行系统发育分析。 学生将接触到进化原理、序列数据库、序列比较和分析、序列相似性搜索、多重序列比对和系统发育树构建。 在本模块结束时，学生应该了解生物信息学资源的应用，以阐明序列数据集中重要且相关的进化信息。 该模块将重点关注使用系统发育学进行功能分配，识别基因之间的同源关系，并构建生物体之间的系统发育。 本课程将在高年级分子生物学、遗传学、微生物学或进化论课程中教授，并将在生物学、化学、数学和计算机科学学科之间架起桥梁。 该模块将在各个 PUI 的学年以及 OUHSC 校园的夏季研究项目期间提供两次。 向 OK-INBRE PUI 提供的另一门多学科课程将由来自 OMRF 附属 MRI 核心设施的 Towner 博士教授。 生物医学成像融合了多个学科。 物理和化学用于在原子水平上了解 MRI 中的质子和 CT 扫描中的 X 射线如何生成用于生成可应用于医学诊断的解剖图像的信号。 图像显示和处理涉及数学算法的使用，例如 MRI 中的傅里叶变换。 生物物理过程，例如选择性造影剂摄取、水扩散和灌注，涉及生物学、物理学和化学概念的结合。 MRI 的扩展以获得与病理过程相关的代谢信息涉及对化学和生物化学的强烈依赖。 分子成像结合了分子特异性亲和力成分以及报告或信号传导成分，并借鉴了分子生物学（免疫学、细胞生物学）和化学（分子探针的合成、药代动力学）。 成像分析涉及使用数学和计算机编程对从数据中获得的形态、分子、功能和代谢信息进行后处理和定量评估。该 Bio2010 模块将针对生物化学、化学、免疫学、细胞生物学和物理学领域的高年级本科生。 该模块将在学年以及 OMRF 的夏季研究计划期间提供两次（有关这两个新的 Bio2010 多学科模块课程的详细大纲和教学大纲，请参阅附录）。