BIO2010

生物2010

• 批准号: 8359645
• 负责人: Rheal A Towner
• 金额: $ 10.28万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359645
• 关键词: Academy; Affinity; Biochemistry; Bioinformatics; Biology; Biomedical Research; Biophysical Process; Calendar; Cellular biology; Charge; Chemistry; Contrast Media; Core Facility; Data; Data Set; Databases; Diagnosis; Discipline; District of Columbia; Drug Kinetics; Education; Educational Curriculum; Educational process of instructing; Evolution; Funding; Genes; Genetic; Goals; Grant; Image; Image Analysis; Immunology; Institution; Internet; Magnetic Resonance Imaging; Mathematics; Medical; Metabolic; Microbiology; Modeling; Molecular; Molecular Biology; Molecular Probes; National Center for Research Resources; National Research Council; Oklahoma; Organism; Pathologic Processes; Perfusion; Phylogenetic Analysis; Phylogeny; Physics; Principal Investigator; Process; Protons; Reliance; Reporting; Research; Research Infrastructure; Resources; Roentgen Rays; Science; Sequence Alignment; Sequence Analysis; Signal Transduction; Source; Students; Synthesis Chemistry; Trees; United States National Academy of Sciences; United States National Institutes of Health; X-Ray Computed Tomography; bioimaging; computer program; computer science; cost; expectation; mathematical algorithm; molecular imaging; multidisciplinary; programs; uptake; water diffusion

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. OK-INBRE undergraduate partner institutions is now charged with considering how to "reinvent" Oklahoma's undergraduate science curriculum along the lines of the Bio2010 model (Bio2010: Transforming Undergraduate Education for Future Research Biologists, by the National Research Council of the National Academies, 2003; National Academies of Science, Washington, DC). It is our expectation that these curriculum changes will be implemented incrementally during the next round of OK-INBRE funding. To begin this new type of multidisciplinary teaching, in the next funding period, we propose to provide to PUI students two different week-long course modules developed by the Bioinformatics and accessory MRI Core facility directors. Briefly, the course provided by Dr. Dyer and the Bioinformatics Core has the goal of introducing the students to phylogenetic analyses using free bioinformatics resources available from the web. The students will be exposed to the principles of evolution, sequence databases, sequence comparisons and analyses, sequence similarity searching, multiple sequence alignments, and phylogenetic tree building. Towards the end of this module, the students should understand the applications of bioinformatics resources towards elucidating important and relevant evolutionary information from a sequence dataset. The module will focus on using phylogenetics to make functional assignments, identify homologous relationships between genes, and construct phylogenies between organisms. This course will be taught in upper division molecular biology, genetics, microbiology, or evolution courses and will bridge the disciplines of biology, chemistry, mathematics and computer science. The module will be offered twice in the academic calendar year at various PUIs, as well as during the summer research program on the OUHSC campus. The other multidisciplinary course to be offered to the OK-INBRE PUIs will be taught by Dr. Towner from the accessory MRI core facility located at the OMRF. Biomedical imaging incorporates multiple disciplines. Physics and chemistry are used to understand at the atomic level how protons in MRI and X-rays in CT scans can generate the signals used to generate anatomical images that can be applied for medical diagnosis. Image display and processing involves the use of mathematical algorithms, such as Fourier Transformation in MRI. Biophysical processes, such as selective contrast agent uptake, water diffusion and perfusion, involve combined biology, physics and chemistry concepts. The extension of MRI to obtain metabolic information associated with pathological processes involves a strong reliance on chemistry and biochemistry. Molecular imaging incorporates a molecular-specific affinity component as well as a reporting or signaling component and draws molecular biology (immunology, cell biology) and chemistry (synthesis of molecular probes, pharmacokinetics). Imaging analysis involves the use of mathematical and computer programming for post-processing and quantitative assessment of morphological, molecular, functional and metabolic information that can be obtained from the data. This Bio2010 module will be targeted towards upper division undergraduate students in biochemistry, chemistry, immunology, cell biology, and physics. The module will be offered twice in the academic calendar year, as well as during the summer research program at the OMRF (see Appendix for detailed outlines and syllabi for both of these new Bio2010 multidisciplinary module courses).

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 现在，OK-INBRADRADULE合作伙伴机构现在负责考虑如何沿着Bio2010模型的界线“重塑”俄克拉荷马州的本科科学课程（Bio2010：为未来的研究生物学家改造本科教育，由国家国家研究委员会，由国家国家研究委员会，由国家国家研究委员会，2003年； 2003年；国家科学学院；国家科学学院； 我们期望这些课程更改将在下一轮OK-INBRE资金中逐步实施。 为了开始这种新型的多学科教学，在下一个资助期内，我们建议为PUI学生提供由生物信息学和配件MRI核心设施主管开发的两个不同的一周课程模块。 简而言之，Dyer博士提供的课程和生物信息学核心的目的是将学生使用网络提供的免费生物信息学资源介绍系统发育分析。 学生将暴露于进化原理，序列数据库，序列比较和分析，序列相似性搜索，多个序列比对和系统发育树的建设。 在该模块结束时，学生应该了解生物信息学资源的应用，以从序列数据集阐明重要和相关的进化信息。 该模块将专注于使用系统发育学以进行功能分配，确定基因之间的同源关系，并在生物体之间构建系统发育。 本课程将在上层分子生物学，遗传学，微生物学或进化课程中教授，并将桥接生物学，化学，数学和计算机科学的学科。 该模块将在各种PUI的学术日历年以及OUHSC校园的夏季研究计划中提供两次。 Towner博士将从位于OMRF的附件MRI核心设施中教授其他多学科课程。 生物医学成像结合了多个学科。 物理和化学用于在原子水平上理解MRI和CT扫描中X射线质子的质子如何生成用于生成可用于医学诊断的解剖图像的信号。 图像显示和处理涉及使用数学算法，例如MRI中的傅立叶变换。 生物物理过程，例如选择性对比剂的吸收，水扩散和灌注，涉及生物学，物理和化学概念。 MRI的扩展以获得与病理过程相关的代谢信息的扩展涉及对化学和生物化学的强烈依赖。 分子成像结合了分子特异性亲和力成分以及报告或信号成分，并绘制分子生物学（免疫学，细胞生物学）和化学（分子探针的合成，药代动力学）。 成像分析涉及使用数学和计算机编程在形态，分子，功能和代谢信息的后处理和定量评估中可以从数据中获得的。该BIO2010模块将针对上层分裂的本科生生物化学，化学，免疫学，细胞生物学和物理学。 该模块将在学术日历年以及OMRF的夏季研究计划中提供两次（请参阅附录，有关这两个新的Bio2010多学科模块课程的详细概述和教学大纲）。