COBRE: OK MED RES FOUND: CORE IV: MRI IMAGING IN VIVO

COBRE：发现良好的医学研究成果：核心 IV：体内 MRI 成像

• 批准号: 8168456
• 负责人: Rheal A Towner
• 金额: $ 17.57万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-08 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168456
• 关键词: Bioenergetics; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Core Facility; Disease; Foundations; Funding; Future; Grant; Histology; Image; Image Enhancement; Injury; Institution; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Medical Research; Metabolism; Microscopic; Modeling; Monitor; Monoclonal Antibodies; Oklahoma; Pathogenesis; Physiological; Rattus; Research; Research Personnel; Resolution; Resources; Source; Staging; Techniques; Tissues; Transgenic Mice; United States National Institutes of Health; in vivo; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The general objective of the MRI/MRS Core facility is to provide non-invasive in vivo monitoring capabilities that can be used to assess morphological, physiological, pathophysiological and metabolic processes that occur during progressive stages of the pathogenesis of most diseases. A major focus of the MRI/MRS Core facility is to study the in vivo pathogenesis of various aspects of cardiovascular diseases in experimental transgenic mice or rat models. At least three of the 5 proposed projects will utilize the MRI/MRS Core facility as a major component and significantly benefit from magnetic resonance imaging (MRI) and/or magnetic resonance spectroscopy (MRS) studies. The remaining 2 proposed projects will possibly use MRI and/or MRS techniques in future proposed in vivo projects. As a result it is of the utmost importance that the MRI/MRS Core is established and that it directly interacts with each of the researchers respective to the proposed projects as discussed in further detail below. The core will be able to specifically provide in vivo (1) morphological assessment that will provide "microscopic" histology information in any cardiovascular-associated tissue or vascular vessel up to 100 #m resolution, (2) vascular specific images in the form of magnetic resonance angiography, (3) vascular flow velocity, (4) contrast agent image enhancement of cardiovascular pathogenesis with the use of recently-developed vascular-specific contrast agents, (5) contrast agent image enhancement of specific endothelial receptors that are involved in the pathogenesis of a cardiovascular disease using newlydeveloped monoclonal antibodies tagged with a contrast agent, and (6) metabolic processes relating to changes in either tissue injury or bioenergetics. The MRI/MRS Core facility will be established in the newly-proposed Oklahoma Medical Research Foundation MRI/MRS Facility located in the Bell Building, under the direction of Dr. Rheal A. Towner.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 MRI/MRS核心设施的一般目标是提供非侵入性体内监测能力，可用于评估大多数疾病发病机理的阶段性阶段中发生的形态，生理，病理生理和代谢过程。 MRI/MRS核心设施的主要重点是研究实验性转基因小鼠或大鼠模型中心血管疾病各个方面的体内发病机理。拟议的5个项目中至少有三个将利用MRI/MRS核心设施作为主要组成部分，并从磁共振成像（MRI）和/或磁共振光谱（MRS）研究中显着受益。其余的两个拟议项目可能会在未来建议的体内项目中使用MRI和/或MRS技术。结果，建立MRI/MRS MRS MRS CORE并直接与每个研究人员与所提议的项目相互作用至关重要，如下所述的进一步详细讨论。核心将能够特异性地提供体内（1）形态评估，该评估将在任何心血管相关的组织或血管血管中提供“微观”的组织学信息，最多可分辨率为100 #m，（2）磁共振血管造影的形式中的血管特定图像，（3）血管流动性（3）使用（3）使用（3）使用（4）对比度的（4）使用图像的形式（4）最近开发的血管特异性对比剂，（5）使用新生长的单克隆抗体与对比度抗体，（6）与组织损伤有关的代谢过程的对比剂图像增强了患心血管疾病的发病机理的对比剂图像增强。 MRI/MRS核心设施将在俄克拉荷马州医学研究基金会的MRI/太太设施中建立，位于钟楼，在Rheal A. Towner博士的指导下。