MRI CORE

核磁共振核心

• 批准号: 7960006
• 负责人: Rheal A Towner
• 金额: $ 14.36万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960006
• 关键词: Ablation; Angiography; Animals; Bioenergetics; Biomedical Research; Brain; Brain Neoplasms; Breast; Choline; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Creatine; Development; Disease; Experimental Animal Model; Funding; Grant; Image; Institution; Investigation; Lasers; Lesion; Lipids; Liquid substance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetism; Malignant Neoplasms; Malignant neoplasm of brain; Metabolic; Methods; Microscopic; Microscopy; Modeling; Molecular; Molecular Target; Monitor; Mus; Oklahoma; Organ; Pathogenesis; Phase; Phospholipids; Rattus; Research; Research Personnel; Resolution; Resources; Rodent; Source; Spectrum Analysis; Techniques; Technology; Temperature; Therapeutic Agents; Tissues; United States National Institutes of Health; Vascular System; base; design; imaging modality; imaging probe; in vivo; instrument; magnetic field; melanoma; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. At OMRF and OUHSC we utilize high-resolution MR techniques (including microscopic imaging and spectroscopy) for biomedical research. The use of rodent experimental animal models has dramatically advanced our ability to analyze and understand the molecular basis of various diseases, however few methods exist to be able to visualize the various tissues, organs and vascular systems of rodents in vivo and non-invasively at any meaningful resolution. The following instrument, a Bruker Biospin Biospec 70/30 USR horizontal magnetic small animal imaging spectrometer, is capable of obtaining in vivo microimages (at ~100 ¿m resolution or better for microscopic MRI) in rodent experimental animal models, and in addition provide in vivo functional information on molecular targets (contrast-enhanced MRI) as well as structural information on metabolites, such as lipids/phospholipids, bioenergetic compounds, creatine, choline, and lactate (using magnetic resonance spectroscopy (MRS)). Magnetic resonance imaging (MRI), and its related techniques in biomedical research, such as MR angiography (MRA), MR spectroscopy (MRS), have developed over the past few years with significant advances in high-field magnets, high-strength magnetic field gradients, imaging probe designs and tissue-specific contrast agents, which have allowed selective morphological, functional and metabolic investigations in mice and rats to be possible. Another recent advancement in MR technology has been the development of MR microscopy. Images can be obtained with in-plane resolutions better than 100 micron, and in-vivo spectra can be collected with sensitivity and spectral resolution previously obtained only by narrow-bore liquid NMR spectrometers. Morphological MRI and/or microscopic MRI (~100 ¿m resolution) is currently used in our facility to localize and determine the extent of brain cancer lesions in a rat model (Towner) and breast and/or melanoma cancer lesions in rats and mice (Chen), and to monitor temperature changes in laser-induced tumor ablation with the use of phase-sensitive and chemicla-shift imaging (CSI) methods(Chen). Magnetic resonance spectroscopy (MRS), using image-guided MRS, is also used to monitor metabolic profiles for rat brain tumor pathogenesis (lipid and brain metabolite alterations; Towner), as well as assess therapeutic agents (Towner).

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 在OMRF和OUHSC，我们利用高分辨率MR技术（包括微观成像和光谱法）进行生物医学研究。使用啮齿动物的动物模型的使用极大地提高了我们分析和理解各种疾病的分子基础的能力，但是在任何有意义的分辨率下，都有很少有方法能够可视化啮齿动物的各种时机，器官和啮齿动物的血管系统。以下仪器是Bruker Biospin Biospec 70/30 USR水平磁性小动物成像光谱仪，能够在啮齿动物实验动物模型中获得体内微型图像（在〜100 〜100»M resolution或更好地分辨率或更好的显微镜MRI）中，此外，还提供了在MRII以及对相反的MRI的VIVO函数信息中，以及在MRI上提供的信息，以及MRI的函数信息）。脂质/磷脂，生物能化合物，创造，胆碱和乳酸（使用磁共振光谱（MRS））。 磁共振成像（MRI）及其在生物医学研究中的相关技术，例如MR血管造影（MRA），MR Spectroscopicy（MRS）在过去几年中已经发展，在高原磁铁，高强度磁场梯度，探针设计和组织特异性造成同时的高度磁场梯度，高强度磁场梯度的显着进步中，可以选择性地进行培养和调查。 MR技术最近的另一个进步是MR显微镜的发展。可以用比100微米更好的面内分辨率获得图像，并且可以以敏感性和光谱分辨率以前仅通过狭窄孔液体NMR光谱仪获得的灵敏度和光谱分辨率收集。 Morphological MRI and/or microscopic MRI (~100 ¿m resolution) is currently used in our facility to localize and determine the extent of brain cancer lesions in a rat model (Towner) and breast and/or melanoma cancer lesions in rats and mice (Chen), and to monitor temperature changes in laser-induced tumor ablation with the use of phase-sensitive and chemical-shift imaging (CSI) methods(Chen).使用图像引导的MRS，磁共振光谱（MRS）也用于监测代谢特征的大鼠脑肿瘤发病机理（脂质和脑代谢物改变； Towner）以及评估治疗剂（Towner）。