COCAINE & MATERNAL AGGRESSION--OXYTOCINERGIC MECHANISMS
可卡因
基本信息
- 批准号:6607455
- 负责人:
- 金额:$ 28.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-07-01 至 2006-06-30
- 项目状态:已结题
- 来源:
- 关键词:aggression amitriptyline amygdala autoradiography behavioral /social science research tag cocaine desipramine embryo /fetus toxicology fluoxetine hormone receptor hormone regulation /control mechanism in situ hybridization laboratory rat lactation maternal behavior oxytocin paraventricular nucleus postpartum pregnancy preoptic areas psychopharmacology radioimmunoassay receptor binding tegmentum
项目摘要
DESCRIPTION (applicant's abstract): Cocaine abuse by human mothers is
correlated with a high incidence of child neglect and abuse. Gestational
cocaine (COC) treatment has been shown to increase aggression towards an
intruder (maternal aggression) and reduce the levels of oxytocin (OXY) in the
amygdala of rats on postpartum days (PPD) 6-10. Blocking OXY receptors in the
central amygdala results in an increase in aggression parallel to that seen
following COC treatment. COC likely decreases OXY in the amygdala and increases
maternal aggression through its reuptake inhibition of dopamine (DA), serotonin
(5-HT) and norepinephrine (NE). These studies are designed to elucidate the
specific mechanisms through which COC may work to alter OXY and maternal
aggression in rats.
Specific Aim 1 will determine if gestational treatment with a combination
treatment of selective DA and 5-HT uptake inhibitor will increase maternal
aggression as does COC. To test this hypothesis, groups of rat dams will be
treated gestationally (days 1-20) with COC, control vehicle buffer (VCB),
selective DA, 5-HT, or NE reuptake inhibitors or combinations of selective
inhibitors. Dams will be tested for maternal aggression on PPD 6.
Specific Aim 2 will determine if gestational treatment with a combination of a
selective DA and 5-HT uptake inhibitor will alter OXY dynamics as does COC. To
test this hypothesis, groups of rat dams will be treated gestationally (days
1-20) with vehicle buffer (VCB), COC, selective DA, 5-HT, or NE reuptake
inhibitors or combinations of the selective inhibitors and sacrificed on PPD 6.
OXY levels and receptor binding will be measured by radioimmunoassay, in situ
hybridization and autoradiography in the amygdala, medial preoptic area and
paraventricular nucleus of the hypothalamus, all of which have been implicated
in OXY regulation of maternal aggression.
Specific Aim 3 will determine if gestational COC treatment reduces OXY
synthesis in the medial preoptic area and paraventricular nucleus and oxytocin
receptor (OTR) synthesis in the amygdala, medial preoptic area and
paraventricular nucleus. To test this hypothesis, rat dams will be treated
gestationally with VCB or COC, and these brain regions removed for in situ
hybridization and autoradiography for assessment of OXY and OTR messenger
ribonucleic acid on PPD 6.
Specific Aim 4 will determine if prenatal exposure to COC and being raised by a
COC treated mother as compared to being raised by mothers treated with control
vehicle increases maternal aggression displayed by female offspring and
decreases OXY in the amygdala of the offspring as adults. To test this
hypothesis, female offspring of dams gestationally treated with COC or control
vehicle buffer (2 groups, buffer with no pair feeding and buffer with pair
feeding), will be raised by their natural dams or foster dams that are
vehicle-treated (pair-fed and non-pair-fed) or COC and then bred and tested for
maternal aggression in the presence of their own litters on PPD 6. OXY levels
in the amygdala will be assessed following the behavioral testing.
描述(申请人摘要):人类母亲滥用可卡因是
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Josephine M. Johns其他文献
Josephine M. Johns的其他文献
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{{ truncateString('Josephine M. Johns', 18)}}的其他基金
Neurobiological and Behavioral Consequences of Cocaine Use in Mother/Infant Dyads
母婴二人使用可卡因的神经生物学和行为后果
- 批准号:
8641444 - 财政年份:2013
- 资助金额:
$ 28.88万 - 项目类别:
MR MICROSCOPY OF A RAT PRENATAL COCAINE EXPOSURE MODEL
大鼠产前可卡因暴露模型的 MR 显微镜检查
- 批准号:
8363193 - 财政年份:2011
- 资助金额:
$ 28.88万 - 项目类别:
MR MICROSCOPY OF A RAT PRENATAL COCAINE EXPOSURE MODEL
大鼠产前可卡因暴露模型的 MR 显微镜检查
- 批准号:
8171624 - 财政年份:2010
- 资助金额:
$ 28.88万 - 项目类别:
Neurobiological and Behavioral Consequences of Cocaine Use in Mother/Infant Dyads
母婴二人使用可卡因的神经生物学和行为后果
- 批准号:
7851416 - 财政年份:2008
- 资助金额:
$ 28.88万 - 项目类别:
Neurobiological and Behavioral Consequences of Cocaine Use in Mother/Infant Dyads
母婴二人使用可卡因的神经生物学和行为后果
- 批准号:
8089463 - 财政年份:2008
- 资助金额:
$ 28.88万 - 项目类别:
Neurobiological and Behavioral Consequences of Cocaine Use in Mother/Infant Dyads
母婴二人使用可卡因的神经生物学和行为后果
- 批准号:
7673489 - 财政年份:2008
- 资助金额:
$ 28.88万 - 项目类别:
Neurobiological and Behavioral Consequences of Cocaine Use in Mother/Infant Dyads
母婴二人使用可卡因的神经生物学和行为后果
- 批准号:
9066232 - 财政年份:2008
- 资助金额:
$ 28.88万 - 项目类别:
Neurobiological and Behavioral Consequences of Cocaine Use in Mother/Infant Dyads
母婴二人使用可卡因的神经生物学和行为后果
- 批准号:
8268547 - 财政年份:2008
- 资助金额:
$ 28.88万 - 项目类别:
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