ABSOLUTE CEREBRAL BLOOD FLOW QUANTIFICATION WITH ASL DURING HYPEROXIA

高氧期间使用 ASL 进行绝对脑血流定量

• 批准号: 8362014
• 负责人: David Pilkinton
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362014
• 关键词: Animal Model; Blood; Breathing; Cerebrovascular Circulation; Complication; Core-Binding Factor; Data; Funding; Grant; Hyperoxia; Literature; Magnetic Resonance; Measurement; Measures; Modeling; National Center for Research Resources; Oxygen; Physiologic pulse; Principal Investigator; Rattus; Research; Research Infrastructure; Research Personnel; Resources; Source; Spin Labels; United States National Institutes of Health; base; cost; in vivo; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Several studies have used arterial spin labeling (ASL) approaches to investigate the regional CBF changes with hyperoxia. Although it is well-known that inhaled oxygen creates a significant reduction in the T1 of arterial blood (T1a), and that T1a has a substantial effect on CBF measurements using ASL, only a small number of these studies have incorporated these T1a changes in their CBF calculations. For these studies, some investigators used the results of prior studies of T1a during hyperoxia to estimate an average expected change in T1a. Others were required to model the expected change in T1a because the study was performed at 3 Tesla (T), where there is no literature data available on T1a during hyperoxia. These approaches may be problematic for several reasons. In this project, our aim was to simultaneously measure CBF and T1a in vivo during normoxia and hyperoxia using pulsed ASL approaches. This will allow for an accurate correction of CBF data due to reduction in T1a on a per subject basis, allowing for the quantification of the degree to which the reduction in CBF measured with ASL are due to T1a. Rats are used as animal model in this case because of the complication of spins flowing in from outside of the transmit coil.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 一些研究使用动脉自旋标记（ASL）方法来研究高氧下局部CBF的变化。 尽管众所周知，吸入氧气会显著降低动脉血的T1（T1 a），并且T1 a对使用ASL进行的CBF测量有显著影响，但只有少数研究将这些T1 a变化纳入CBF计算中。 在这些研究中，一些研究者使用先前高氧期间T1 a研究的结果来估计T1 a的平均预期变化。 其他人需要对T1 a的预期变化进行建模，因为研究是在3特斯拉（T）下进行的，在高氧期间没有关于T1 a的文献数据。 由于若干原因，这些方法可能存在问题。 在这个项目中，我们的目的是同时测量CBF和T1 a在体内正常氧和高氧使用脉冲ASL的方法。 这将允许基于每例受试者准确校正由于T1 a降低而导致的CBF数据，允许量化使用ASL测量的CBF降低因T1 a而导致的程度。 在这种情况下，大鼠被用作动物模型，因为自旋从发射线圈的外部流入的并发症。