CHARACTERIZATION OF PARAMAGNETIC EFFECTS OF MOLECULAR OXYGEN

分子氧顺磁效应的表征

• 批准号: 8362013
• 负责人: David Pilkinton
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362013
• 关键词: Blood; Body Fluids; Brain; Contrast Media; Funding; Goals; Grant; Human; Hyperoxia; Image; Magnetic Resonance; Molecular; National Center for Research Resources; Oxygen; Physiology; Principal Investigator; Relaxation; Research; Research Infrastructure; Resources; Source; Tissues; United States National Institutes of Health; Weight; blood oxygen level dependent; cost; deoxyhemoglobin; frontal lobe; magnetic field; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In hyperoxic contrast studies modulated by the blood oxygenation level-dependent (BOLD) effect, it is often that hyperoxia is a purely intravascular, positive contrast agent in T2*-weighted images, and the effects that are not due to BOLD contrast are small enough to be ignored. In this project, we reevaluated this assumption, with the goal of characterizing non-BOLD effects in T2*-weighted hyperoxic contrast studies. The quality of oxygen as an intravascular contrast agent depends not only on its minimal effects on the underlying physiology, but also on its minimal relaxation effects not due to the dilution of deoxyhemoglobin. Although it is known that molecular oxygen dissolved in the blood has a relatively weak T2 and T1 relaxivities molecular oxygen has been shown to be effective as a T1 contrast agent in body fluids, with a fast wash-in of a significant concentration of molecular oxygen into these tissues. Another important effect is the disruption of the static magnetic field (B0) in the frontal lobes of the brain due to the influence of paramagnetic gaseous oxygen in the upper airway, which has not yet been characterized in hyperoxic contrast studies of the human brain.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 在由血氧水平依赖性 (BOLD) 效应调节的高氧对比研究中，高氧通常是 T2* 加权图像中纯粹的血管内、阳性对比剂，并且非 BOLD 对比造成的影响小到足以忽略不计。 在本项目中，我们重新评估了这一假设，目标是表征 T2* 加权高氧对比研究中的非 BOLD 效应。 作为血管内造影剂的氧气的质量不仅取决于其对基础生理学的最小影响，还取决于其不是由于脱氧血红蛋白稀释而产生的最小松弛效应。 尽管众所周知，溶解在血液中的分子氧具有相对较弱的 T2 和 T1 弛豫率，但分子氧已被证明可作为体液中的 T1 造影剂，具有有效浓度的分子氧快速冲入这些组织中的作用。 另一个重要的影响是由于上呼吸道顺磁气态氧的影响而导致大脑额叶静磁场（B0）的破坏，这在人脑高氧对比研究中尚未得到表征。