SPIN-LOCK SODIUM MRI OF THE HUMAN BRAIN

人脑自旋锁钠 MRI

• 批准号: 7955340
• 负责人: David Pilkinton
• 金额: $ 0.56万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955340
• 关键词: Binding; Binding Sites; Biological; Brain; Cell Nucleus; Characteristics; Complex; Computer Retrieval of Information on Scientific Projects Database; Data; Degenerative polyarthritis; Electrostatics; Environment; Frequencies; Funding; Grant; Human; Institution; Knowledge; Literature; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Molecular; Motion; Pathology; Protons; Reporting; Research; Research Personnel; Resources; Sodium; Source; Spectrum Analysis; Stroke; Tissues; United States National Institutes of Health; Water; base; density; macromolecule; optical imaging; sodium ion

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Proton T1¿ MRI studies have shown that spin-locking can provide unique and clinically-useful contrast correlated to macromolecular content due to its ability to probe slow molecular motion. Although spin-locking spectroscopy of sodium has been investigated as a means to selectively detect sodium nuclei involved in slow molecular motion and anisotropic environments, to knowledge there is currently no literature reporting spin-lock sodium MRI data. A large fraction of sodium ions in biological tissue are complexed to macromolecules through electrostatic binding sites and their interactions with the bound water fraction. Several tissue pathologies, e.g. stroke and osteoarthritis, involve substantial changes to motional characteristics of the complexed fraction of sodium spins. Measurements of T2 or T2* are sensitive to slow motion only through the spectral density at zero frequency; slow dynamics are probed more efficiently through the application of a strong RF fields in the sub-kilohertz range. We hypothesize that spin-lock sodium MRI will generate significant contrast based on macromolecular content in biological tissue due to its sensitivity to slow molecular motion.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 Proton T1¿ MRI 研究表明，自旋锁定可以提供独特且具有临床用途的 由于其能够探测慢分子运动，对比度与大分子含量相关。 尽管钠的自旋锁定光谱已被研究作为选择性地 检测参与慢分子运动和各向异性环境的钠核， 目前尚无文献报道自旋锁钠 MRI 数据。 很大一部分 生物组织中的钠离子通过静电结合与大分子络合 位点及其与结合水部分的相互作用。 几种组织病理学，例如中风 和骨关节炎，涉及复合部分运动特征的实质性变化 钠自旋。 T2 或 T2* 的测量仅通过光谱对慢运动敏感 零频率密度；通过应用更有效地探测慢动态 亚千赫兹范围内的强射频场。 我们假设自旋锁钠 MRI 将产生 由于其对慢速的敏感性，基于生物组织中大分子含量的显着对比 分子运动。