MAPPING FINE SCALE OLFACTORY SENSORY REPRESENTATIONS IN THE CORTEX

绘制大脑皮层的精细嗅觉表征

• 批准号: 8361927
• 负责人: Kristin Kay Baldwin
• 金额: $ 3.7万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361927
• 关键词: Brain; Code; Fright; Funding; Genes; Grant; Image Analysis; Instinct; Learning; Maps; Memory; Mus; National Center for Research Resources; Nose; Partner in relationship; Perception; Principal Investigator; Process; Relative (related person); Research; Research Infrastructure; Resources; Sensory; Site; Source; United States National Institutes of Health; cost; experience; neural circuit

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The aim of this project is to reveal the neuroanatomical organization of circuits that underlie olfactory processing. While studies across species have revealed highly conserved olfactory sensory maps in the periphery, far less is known about the circuits that enable olfactory coding and perception in the brain. The primary objective of this project is to map the connectivity of input specific olfactory circuits from the nose to the cortex in the mouse brain. Findings from these studies can consequently be applied to identify cortical sites of integration for distinct olfactory inputs and to dissect the relative contribution of genes and experience in olfactory neural circuit formation and function. These studies should have implications for understanding innate behaviors such as fear and mating and also facilitate the study of learning and memory.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这个项目的目的是揭示神经解剖学组织的电路，嗅觉处理的基础。虽然跨物种的研究揭示了边缘高度保守的嗅觉感觉地图，但对大脑中使嗅觉编码和感知成为可能的回路知之甚少。这个项目的主要目标是映射从鼻子到小鼠大脑皮层的输入特定嗅觉回路的连通性。因此，这些研究的结果可以应用于确定不同的嗅觉输入的整合皮层网站，并剖析基因和经验的嗅觉神经回路的形成和功能的相对贡献。这些研究应该对理解恐惧和交配等先天行为有意义，也有助于学习和记忆的研究。