GENETIC EFFECTS ON TRANSPORTER EXPRESSION IN KIDNEY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 利用人类肾脏样本，已经获得了转运蛋白和选定的转录因子的基因类型和表达水平。将进行关联研究，以寻找重要药物转运蛋白在人类中表达水平变化的遗传决定因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Using human kidney samples, genotypes and expression levels have been obtained for transporters and selected transcription factors. Association studies will be conducted to find genetic determinants of expression level variation in humans for important drug transporters.