MULTIMODAL OPTICAL IMAGING INSTRUMENT AND MODEL FOR ASSESSING TARGETED THERAPIES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们的目标是开发一种独特的体内微血管网络动物模型和专用成像仪器，以实现对新型微血管靶向癌症治疗效果的纵向临床前研究。我们将设计成像设备，以促进解剖和功能动力学的研究。然后，我们将使用该仪器来监测光动力疗法中的解剖和功能动力学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our objective is to develop a unique, in vivo microvascular network animal model and dedicated imaging instrumentation to enable longitudinal preclinical studies on the efficacy of novel microvascular-targeted cancer therapies. We will design imaging instrumentation to facilitate study of anatomical and functional dynamics. Then, we will use this instrument to monitor anatomical and functional dynamics during photodynamic therapy.