MR ANGIOGRAPHY OF FASD MOUSE MODEL

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 对死于婴儿猝死综合征（SIDS）的儿童进行尸检，发现颈动脉体和颈动脉的缺陷是其死亡的潜在致病因素之一。同样，流行病学研究也发现，产前接触乙醇是小岛屿发展中国家某些病例的另一个组成部分。最后，我们实验室的实验已经证明了乙醇诱导的细胞凋亡在发育中的小鼠胚胎区域，这对颈动脉体和颈动脉的正常发育至关重要。本文提出的实验将检验以下假设：早期妊娠乙醇暴露将导致颈动脉体发育不良、对缺氧的正常呼吸反应不足以及头颈部血管系统异常，特别是颈动脉及其近端分支。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Autopsies of children who have died of sudden infant death syndrome (SIDS) have identified deficits of the carotid body and the carotid arteries as one of the potential causative factors in their deaths. Likewise, epidemiological studies have identified prenatal ethanol exposure as another component involved in a certain subset of cases of SIDS. Finally, experiments from our laboratory have demonstrated ethanol-induced apoptotic cell death in regions of the developing mouse embryo that are crucial to the proper development of both the carotid body and carotid arteries. The experiments proposed here will test the hypotheses that early gestional ethanol exposure will result in hypoplasia of the carotid body, deficits in the normal respiratory response to hypoxia and abnormal vasculature of the head and neck, particularly the carotid arteries and their proximal branches.