USING ARTERIAL SPIN LABEL AND PWI TO MEASURE QUANTITATIVE CBF

使用动脉旋转标签和 PWI 定量测量 CBF

• 批准号: 8362921
• 负责人: Gregory George Zaharchuk
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362921
• 关键词: Annual Reports; Arteriogram; Bolus Infusion; Cerebrovascular Circulation; Funding; Gold; Grant; Image; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Methods; National Center for Research Resources; Perfusion; Predisposition; Principal Investigator; Reading; Research; Research Infrastructure; Resources; Source; Spin Labels; Technology; Time; Uncertainty; United States National Institutes of Health; Visit; Weight; Xenon; abstracting; blood flow measurement; comparative; cost; factor A; human AMID protein; improved; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bolus PWI Measurement Of Quantitative CBF Can Be Improved Using An Arterial Spin Label Derived Scaling Factor: A Comparative Xenon CT Study Bolus dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWI) and arterial spin labeling (ASL) are two methods of measuring cerebral blood flow (CBF) using MRI. Each has different strengths and weaknesses. ASL CBF levels are reliable in high flow regions, but suffer from errors and low SNR in regions with long arterial arrival times. PWI, particularly when using delay-invariant deconvolution, is in theory unaffected by long arrival times. However, absolute quantitation is challenging, due to uncertainties in AIF & VOF partial volume and the nonlinear relationship between transverse relaxivity and contrast concentration. This study describes a method that uses ASL CBF measurements in regions with short transit delays (as measured by Tmax) to scale PWI CBF measurements. Stable xenon CT was used as a gold standard for CBF. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 使用动脉旋转标签衍生的缩放因子可以改进定量 CBF 的推注 PWI 测量：A 比较氙气 CT 研究 推注动态磁化率对比 (DSC) 灌注加权成像 (PWI) 和动脉自旋标记 (ASL) 是两种 使用 MRI 测量脑血流量 (CBF) 的方法。每个都有不同的优点和缺点。 ASL CBF 水平 在高流量区域是可靠的，但在动脉到达时间较长的区域会出现错误且信噪比较低。脉冲加权平均指数, 特别是当使用延迟不变反卷积时，理论上不受长到达时间的影响。然而，绝对 由于 AIF 和 VOF 部分体积的不确定性以及两者之间的非线性关系，定量具有挑战性 横向弛豫率和对比浓度。本研究描述了一种使用 ASL CBF 测量的方法 具有短传输延迟（通过 Tmax 测量）的区域来扩展 PWI CBF 测量。使用稳定氙 CT 作为 CBF 的黄金标准。 要了解卢卡斯中心正在进行的其他项目，请访问 http://rsl.stanford.edu/（卢卡斯年度报告和 ISMRM 2011 摘要）