USING ARTERIAL SPIN LABEL AND PWI TO MEASURE QUANTITATIVE CBF

使用动脉旋转标签和 PWI 定量测量 CBF

• 批准号: 8362921
• 负责人: Gregory George Zaharchuk
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362921
• 关键词: Annual Reports; Arteriogram; Bolus Infusion; Cerebrovascular Circulation; Funding; Gold; Grant; Image; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Methods; National Center for Research Resources; Perfusion; Predisposition; Principal Investigator; Reading; Research; Research Infrastructure; Resources; Source; Spin Labels; Technology; Time; Uncertainty; United States National Institutes of Health; Visit; Weight; Xenon; abstracting; blood flow measurement; comparative; cost; factor A; human AMID protein; improved; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bolus PWI Measurement Of Quantitative CBF Can Be Improved Using An Arterial Spin Label Derived Scaling Factor: A Comparative Xenon CT Study Bolus dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWI) and arterial spin labeling (ASL) are two methods of measuring cerebral blood flow (CBF) using MRI. Each has different strengths and weaknesses. ASL CBF levels are reliable in high flow regions, but suffer from errors and low SNR in regions with long arterial arrival times. PWI, particularly when using delay-invariant deconvolution, is in theory unaffected by long arrival times. However, absolute quantitation is challenging, due to uncertainties in AIF & VOF partial volume and the nonlinear relationship between transverse relaxivity and contrast concentration. This study describes a method that uses ASL CBF measurements in regions with short transit delays (as measured by Tmax) to scale PWI CBF measurements. Stable xenon CT was used as a gold standard for CBF. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 使用动脉自旋标记衍生的比例因子可以改善定量CBF的团注PWI测量：A 氙气CT对比研究 团注动态磁化率对比(DSC)、灌注加权成像(PWI)和动脉自旋标记(ASL)是两种 磁共振测量脑血流量的方法。每一种都有不同的优势和劣势。ASL CBF水平 在高流量地区是可靠的，但在动脉到达时间较长的地区会出现误差和低信噪比。PWI， 特别是当使用延迟不变的反卷积时，理论上不受长到达时间的影响。然而，绝对的 由于AIF和VOF部分体积的不确定性以及AIF和VOF之间的非线性关系，量化是具有挑战性的 横向弛豫度和对比度浓度。这项研究描述了一种使用ASL CBF测量的方法 运输延迟较短的地区(以Tmax衡量)，以衡量PWI CBF测量结果。使用稳定的氙气CT作为一种 CBF的黄金标准。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/(卢卡斯年度报告和 ISMRM 2011年摘要)