Oxygenation Fingerprinting with MRI for Ischemic Stroke

缺血性中风的 MRI 氧合指纹图谱

• 批准号: 8827866
• 负责人: Gregory George Zaharchuk
• 金额: $ 20.06万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8827866
• 关键词: Acute; Attention; Biological Markers; Blood; Blood Volume; Brain; Brain Neoplasms; Caring; Cell Death; Cerebrum; Chronic; Clinical; Complement; Decision Making; Development; Dictionary; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Edema; Event; Failure; Fingerprint; Functional Magnetic Resonance Imaging; Gases; Growth; Health; Hemoglobin; Hypoxia; Image; Injury; Ischemia; Ischemic Stroke; Learning; Lesion; Light; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methodology; Methods; Modeling; Motivation; Multiple Sclerosis; Natural History; Neurodegenerative Disorders; Noise; Outcome; Oxygen; Patient Triage; Patients; Performance; Perfusion; Phase; Physiological; Pilot Projects; Plague; Positron-Emission Tomography; Predisposition; Protocols documentation; Recruitment Activity; Relaxation; Reperfusion Therapy; Role; Scanning; Selection Criteria; Signal Transduction; Steno; Stroke; Superior sagittal sinus; Techniques; Testing; Tissues; Triage; Weight; Work; acute stroke; base; blood oxygen level dependent; cohort; deoxyhemoglobin; high reward; high risk; image guided; improved; insight; interest; nervous system disorder; novel strategies; prospective; research study; tissue oxygenation

DESCRIPTION (provided by applicant): MOTIVATION One of the central events in acute ischemic stroke is the decrease in delivery of oxygen to the brain, which leads to cell death and irreversible injury. To counteract this, the brain has mechanisms to increase its extraction of oxygen from the arterial blood, which can be imaged with oxygen-15 positron emission tomography (PET). Some evidence from PET exists that suggests that regions with increased oxygen extraction fraction (OEF) are particularly vulnerable in ischemic stroke. Given the sensitivity of MRI to paramagnetic deoxy- hemoglobin (the basis of the BOLD effect), it is possible to image tissue oxygen saturation (SO2). The motivation for the current study is to implement and validate two promising MR oxygenation methods, multiparametric quantitative BOLD and MR oxygenation fingerprinting for use in stroke patients. This latter technique builds on pioneering work extending the fingerprinting approach from anatomical to physiological imaging. AIMS AND METHODS Over a two-year period, we aim to perform studies to validate the performance of both of these MR oxygenation imaging protocols in normal subjects exposed to inspired gas challenges that will alter the global brain oxygenation. We will then apply the best of these two techniques to a cohort of acute ischemic stroke patients to determine the performance of the oxygenation-diffusion (O2- DWI) mismatch as a potential improved substitute for the traditional DWI-PWI mismatch. SIGNIFICANCE We believe successful attainment of these aims will markedly improve acute stroke care by validating a non-invasive MRI-based method to assess tissue oxygenation. We believe that there will be wide-reaching benefits to the development of a robust MR oxygenation method in a wide range of other neurological diseases, including carotid steno-occlusive disease, brain tumors, multiple sclerosis, and neurodegenerative disease.

描述（由申请人提供）：动机急性缺血性中风的中心事件之一是向大脑递送氧气的减少，这导致细胞死亡和不可逆转的损伤。为了抵消这一点，大脑具有增加从动脉血中提取氧气的机制，该动脉血液可以用氧气15正电子发射断层扫描（PET）成像。宠物的一些证据表明，含氧分解量增加（OEF）的区域在缺血性中风中特别容易受到伤害。鉴于MRI对顺磁性脱氧 - 血红蛋白的敏感性（BOLD效应的基础），可以对组织氧饱和度进行图像（SO2）。当前研究的动机是实施和验证两种有希望的MR氧合方法，多参数定量BOLD和MR氧合指纹用于中风患者。后一种技术建立在开拓性工作的基础上，将指纹方法从解剖学到生理成像扩展。目的和方法在两年期间，我们旨在进行研究，以验证面临受启发的气体挑战的正常受试者中这两种MR氧合成像方案的性能，这将改变全球脑充氧。然后，我们将把这两种技术中的最佳作用到一组急性缺血性中风患者中，以确定氧合扩散（O2- DWI）不匹配的性能，这是对传统DWI-PWI不匹配的潜在改进的替代品。我们认为，通过验证一种非基于MRI的方法来评估组织氧合的方法，我们认为成功实现这些目标将显着改善急性中风护理。我们认为，在多种其他神经系统疾病中，在包括颈动脉steno-癌性疾病，脑肿瘤，多发性硬化症和神经退行性疾病在内的多种其他神经系统疾病中发展强大的MR氧合方法将带来广泛的好处。

项目成果

MR Vascular Fingerprinting in Stroke and Brain Tumors Models.

• DOI: 10.1038/srep37071
• 发表时间: 2016-11-24
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Lemasson B;Pannetier N;Coquery N;Boisserand LSB;Collomb N;Schuff N;Moseley M;Zaharchuk G;Barbier EL;Christen T
• 通讯作者: Christen T