TRANSPORT ACROSS THE SALMONELLA ENTERICA PDU MICROCOMPARTMENT SHELL

穿过肠沙门氏菌 PDU 微室外壳的运输

• 批准号: 8361680
• 负责人: TODD O YEATES
• 金额: $ 0.48万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361680
• 关键词: Cells; Enterobacteriaceae; Funding; Grant; National Center for Research Resources; Organelles; Pathway interactions; Principal Investigator; Propylene Glycols; Protein Subunits; Proteins; Reaction; Reporting; Research; Research Infrastructure; Resources; Salmonella; Salmonella enterica; Source; Structure; United States National Institutes of Health; base; cost; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bacterial microcompartments are a functionally diverse group of proteinaceous organelles that confine specific reaction pathways in the cell within a thin protein-based shell. The propanediol utilizing (Pdu) microcompartment contains the reactions for metabolizing 1,2-propanediol in certain enteric bacteria, including Salmonella. The Pdu shell is assembled from a few thousand protein subunits of several different types. Here we report the crystal structures of two key shell proteins, PduA and PduT.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 细菌微区室是一组功能多样的蛋白质细胞器，其将细胞中的特定反应途径限制在基于蛋白质的薄壳内。丙二醇利用（Pdu）微室包含在某些肠细菌中代谢1，2-丙二醇的反应， 包括沙门氏菌Pdu外壳是由几千个不同类型的蛋白质亚基组装而成的。在这里，我们报告的晶体结构的两个关键壳蛋白，PduA和PduT。