PROTEIN-BASED ORGANELLE IN ESCHERICHIA COLI

大肠杆菌中基于蛋白质的细胞器

• 批准号: 8361681
• 负责人: TODD O YEATES
• 金额: $ 0.48万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361681
• 关键词: Cells; Complex; Escherichia coli; Ethanolamines; Funding; Grant; Homologous Protein; Metabolism; National Center for Research Resources; Organelles; Principal Investigator; Proteins; Reporting; Research; Research Infrastructure; Resolution; Resources; Source; Structure; United States National Institutes of Health; base; cost; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Many bacterial cells contain proteinaceous microcompartments that act as simple organelles by sequestering specific metabolic processes involving volatile or toxic metabolites. Here we report the three-dimensional (3D) crystal structures, with resolutions between 1.65 and 2.5 angstroms, of the four homologous proteins EutS, EutL, EutK, and EutM) that are thought to be the major shell constituents of a functionally complex ethanolamine utilization (Eut) microcompartment.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 许多细菌细胞含有蛋白质微区室，其通过隔离涉及挥发性或毒性代谢物的特定代谢过程而充当简单的细胞器。在这里，我们报告的三维（3D）晶体结构，分辨率在1.65和2.5埃之间，四个同源蛋白EutS，EutL，EutK和EutM），被认为是功能复杂的乙醇胺利用（Eut）微区室的主要外壳成分。