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RACEMIC PROTEIN CRYSTALLOGRAPHY

RACEMIC PROTEIN CRYSTALLOGRAPHY
外消旋蛋白质晶体学
批准号:
8361686
负责人:
TODD O YEATES
金额:
$0.48万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-04-01 至 2012-03-31

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The 50-residue snake venom protein L-omwaprin and its enantiomer D-omwaprin were prepared by total chemical synthesis. Radial diffusion assays were performed against Bacillus megaterium and Bacillus anthracis; both L- and D-omwaprin showed antibacterial activity against B. megaterium. The native protein enantiomer, made of L-amino acids, failed to crystallize readily. However, when a racemic mixture containing equal amounts of L- and D-omwaprin was used, diffraction quality crystals were obtained.
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STRUCTURE AND FOLDING OF A DESIGNED KNOTTED PROTEIN
  • 批准号:
    8361682
  • 项目类别:
  • 资助金额:
    $0.48万
  • 财政年份:
    2011
  • 负责人:
    TODD O YEATES
  • 依托单位:
SYNTHETIC SYMMETRIZATION TO DETERMINE THE STRUCTURE OF CELA
  • 批准号:
    8361685
  • 项目类别:
  • 资助金额:
    $0.48万
  • 财政年份:
    2011
  • 负责人:
    TODD O YEATES
  • 依托单位:
TRANSPORT ACROSS THE SALMONELLA ENTERICA PDU MICROCOMPARTMENT SHELL
  • 批准号:
    8361680
  • 项目类别:
  • 资助金额:
    $0.48万
  • 财政年份:
    2011
  • 负责人:
    TODD O YEATES
  • 依托单位:
PROTEIN-BASED ORGANELLE IN ESCHERICHIA COLI
  • 批准号:
    8361681
  • 项目类别:
  • 资助金额:
    $0.48万
  • 财政年份:
    2011
  • 负责人:
    TODD O YEATES
  • 依托单位:
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