STRUCTURES OF THE SHELL PROTEINS FROM THE ?-CARBOXYSOME (CCMK1 AND CCMK2)

β-羧基体的壳蛋白结构（CCMK1 和 CCMK2）

• 批准号: 8169255
• 负责人: TODD O YEATES
• 金额: $ 0.19万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169255
• 关键词: Caliber; Carbon; Carbon Dioxide; Computer Retrieval of Information on Scientific Projects Database; Cyanobacterium; Encapsulated; Enzymes; Funding; Goals; Grant; Institution; Organelles; Oxygenases; Protein Subunits; Proteins; Research; Research Personnel; Resources; Shapes; Source; Structure; Structure of molecular layer of cerebellar cortex; Synechocystis; United States National Institutes of Health; carbon fixation; carbonate dehydratase; ribulose-1,5-bisphosphate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Carboxysomes are primitive bacterial organelles that function as a part of a carbon concentrating mechanism (CCM) under conditions where inorganic carbon is limiting. The carboxysome enhances the efficiency of cellular carbon fixation by encapsulating together carbonic anhydrase and the CO2 fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO). The carboxysome has a roughly icosahedral shape with an outer shell between 800 and1500 ¿ in diameter, which is constructed from a few thousand small protein subunits. In the cyanobacterium Synechocystis sp. PCC 6803, the previous structure determination of two homologous shell protein subunits, CcmK2 and CcmK4, elucidated how the outer shell is formed by the tight packing of CcmK hexamers into a molecular layer. The goal of this project is to elucidate the structures of the shell proteins forming the carboxysome.

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