Dartmouth Lung Biology Center for Molecular, Cellular and Translational Research

达特茅斯肺生物学分子、细胞和转化研究中心

• 批准号: 9115188
• 负责人: Bruce A. Stanton
• 金额: $ 118.59万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9115188
• 关键词: Award; Basic Science; Biological; Biological Sciences; Biology; Biotechnology; Businesses; Cause of Death; Cell Nucleus; Centers of Research Excellence; Chronic; Communicable Diseases; Development; Drug Industry; Environment; Extramural Activities; Faculty; Financial Support; Funding; Immunology; Island; Laboratories; Lead; Lung; Lung diseases; Maine; Mentors; Molecular; National Institute of Allergy and Infectious Disease; Pharmacotherapy; Pilot Projects; Positioning Attribute; Principal Investigator; Pseudomonas aeruginosa; Request for Applications; Research; Research Personnel; Research Support; Resources; Respiratory Tract Infections; Strategic Planning; Time; Translational Research; Universities; Vermont; catalyst; clinically relevant; drug discovery; innovation; interest; live cell imaging; medical schools; meetings; microbiome; multidisciplinary; novel therapeutics; pathogen; programs; public health relevance; respiratory; success; tenure track; therapeutic development

DESCRIPTION (provided by applicant): This COBRE III application requests funding to complete the establishment of a free standing, nationally recognized Lung Biology Center (LBC) in the Geisel School of Medicine at Dartmouth. The proposed plan for COBRE III builds upon our successes during COBRE I and II during which time we assembled, from a nucleus of 6 faculty, a critical mass of 32 well funded, tenured and tenure-track principal investigators who conduct inter-/multi-disciplinary research on respiratory infectious diseases. Our LBC faculty share common interests in host-pathogen interactions, the respiratory microbiome, and in drug discovery and therapeutic development. To support the research of our faculty we established three LBC-specific research cores, including a: (1) Host-Pathogen Interaction Core, (2) Live-Cell Imaging Core and (3) Translational Research Core. All of our junior faculty project leaders in COBRE 1/11 have already obtained extramural funding, an impressive record of accomplishment in this funding environment. A COBRE III award will provide essential resources to facilitate the continued development ofthe LBC, provide vital resources to enhance inter/multidisciplinary basic science and translational research in respiratory infectious disease, and is an essential component of our research core business plan to be financially independent by 2018. COBRE III support will enhance the continued mentored development of our junior faculty, including those previously supported by COBRE l/ll, the expansion ofthe research cores and an enhanced Pilot Project Program, and will facilitate mentored, collaborative and/or translational research at Dartmouth. Together with a substantial, and longterm, commitment from Dartmouth and strong collaborative ties with investigators in the Lung Biology and Immunology COBRE programs at the University of Vermont (UVM), the Dartmouth Immunology COBRE, the Dartmouth Quantitative Biological Sciences COBRE, and the INBRE programs at UVM, Dartmouth and the Mt. Desert Island Biological Laboratory (MDIBL) in Maine, we are in an exceptionally strong position to continue to build upon our successes in research on host-pathogen interactions, the respiratory microbiome in CF, and in drug discovery and therapeutic development for respiratory infectious diseases.

描述（由申请人提供）：此索贝尔III申请要求资金完成在达特茅斯Geisel医学院建立自由遗嘱的全国认可的肺部生物学中心（LBC）。拟议的Cobre III计划建立在我们在Cobre I和II期间的成功基础上，在此期间，我们从6位教职员工组成的核心组装了32个临界质量，由32名资助良好，终身制和终身制的主要研究人员进行，他们进行呼吸道感染性疾病的互联/多学科研究。我们的LBC教师在宿主 - 病原体相互作用，呼吸微生物组以及药物发现和治疗发育方面具有共同利益。为了支持我们教师的研究，我们建立了三个LBC特异性研究核心，包括a：（1）宿主 - 病原体相互作用核心，（2）活细胞成像核心和（3）转化研究核心。我们所有在1/11索伯尔1/11的初级教师项目负责人都已经获得了校外资金，这是在这种资金环境中成就的令人印象深刻的记录。 COBRE III奖将为LBC的持续发展提供必要的资源，提供重要的资源来增强呼吸道传染病的跨学科基础科学和翻译研究， 并且是我们研究核心业务计划的重要组成部分，要在2018年之前在财务上独立。CobreIII支持将增强我们的初级教师的持续发展发展，包括先前由Cobre L/LL支持的教师，研究核心的扩展和增强的飞行员项目计划，并将促进Dartmouth的指导，协作和转化研究。加上达特茅斯（Dartmouth）的实质，长期的承诺，以及与佛蒙特大学（UVM）肺部生物学和免疫学cobre计划的调查人员的牢固合作关系，达特茅斯免疫学Cobre，达特茅斯（Dartmouth）定量生物学生物科学的量化生物科学量，以及uvm，uvm，dard and doble and dort of dort and dort and dort and dort and dort of dort and dort and dort of dort and dort and dort of dort and dort of dort and dort and dort and dort。缅因州，我们处于极强的立场，可以继续基于我们在宿主 - 病原体相互作用，CF中的呼吸道微生物组以及药物发现和治疗性发育方面取得成功的成功。