Research Translation Core

研究翻译核心

基本信息

批准号：
8254507
负责人：
Joel D Schwartz
金额：
$ 15.73万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8254507
关键词：
Academia Academy Address American Arsenic Bangladesh Basic Science Biological Availability Biological Markers Boston Case Study Chemistry Childhood Clinic Clinical Collaborations Communication Community Outreach Consult Data Decision Making Decision Theory Development Ecology Economics Educational workshop Ensure Environment Environmental Health Epidemiology Exposure to Faculty General Population Genes Genetic Predisposition to Disease Goals Government Agencies Interest Group Journals Lead Mails Manganese Metals Methodology Occupational Oral Oxidation-Reduction Pediatrics Peer Review Policies Policy Developments Policy Maker Population Public Health Public Policy Publications Publishing Relative (related person)Research Research Personnel Research Training Risk Risk Assessment Science Policy Series Site Societies Students Superfund Tars Techniques Technology Training Programs Translating Translational Research United States National Institutes of Health Universities Work Writing base college community organizations data modeling environmental toxicology gene environment interaction genetic epidemiology interest land use medical specialties meetings member metal poisoning neurodevelopment novel outreach program policy implication programs remediation sensor special interest group symposium tool web site

项目摘要

The goal of the Research Translation Core is to actively communicate important research findings emanating from the program in the manner most appropriate for the intended audience, with the goal of ensuring the accurate and timely use of data. The Research Translation Core is organized through the Harvard Center for Risk Analysis (HCRA). HCRA, founded in 1989, has always enjoyed extensive collaboration with and support from regulatory agencies, corporations, interest groups, and colleagues at many universities in the US and abroad, and provides an existing base from which to interpret and disseminate research results to a variety of stakeholders and technical audiences. Much of the integration across specific projects and cores is accomplished through HCRA's demonstrated ability to synthesize and interpret research results in terms of relevance to risk-based environmental decision-making. We will evaluate and synthesize the results of the specific projects and cores in terms of the implications for risk assessment and subsequent decision-making and policy development using case studies and examples for dissemination through HCRA-led publications, conferences, seminars, workshops, and the SBRP and HCRA websites, as well as through community outreach programs. Potential neurodevelopmental risks as a result of exposure to mixtures of arsenic, manganese, and lead in the environment depend on the mobility and bioavailability of the constituents under different environmental conditions as well as potential genetic susceptibility of exposed populations. The Research Translation Core, through the use of case studies and focused integrative analyses, will demonstrate and communicate the public health implications of changes in bioavailability on exposure, genetic susceptibility relative to population risks, and potential biomarkers of exposure and effect to facilitate risk assessment.

研究翻译核心的目的是以最适合预期受众的方式积极地传达从计划中发出的重要研究结果，以确保准确，及时地使用数据。研究翻译核心是通过哈佛风险分析中心（HCRA）组织的。 HCRA成立于1989年，一直与美国和国外许多大学的监管机构，公司，利益集团和同事的广泛合作和支持，并提供了一个现有的基础，可以从中解释和将研究结果解释和传播为各种利益相关者和技术受众。通过HCRA证明的与基于风险的环境决策相关的研究结果，通过HCRA证明的能力来完成跨特定项目和核心的大部分集成。我们将根据对风险评估以及随后的决策和政策制定的影响，评估和综合特定项目和核心的结果，并使用案例研究和示例通过HCRA领导的出版物，会议，研讨会，研讨会以及SBRP和HCRA网站，以及通过社区外展计划。由于暴露于砷，锰和环境中铅的混合物的结果，潜在的神经发育风险取决于成分在不同环境条件下的迁移率和生物利用度以及暴露群体的潜在遗传易感性。研究翻译核心通过使用案例研究和集中综合分析，将证明和传达生物利用度变化的公共卫生影响暴露，相对于人口风险的遗传敏感性以及暴露和影响的潜在生物标志物，以促进风险评估。