Research Translation Core

研究翻译核心

• 批准号: 7932382
• 负责人: Joel D Schwartz
• 金额: $ 17.26万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-12 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7932382
• 关键词: Arsenic; Basic Science; Biological Availability; Biological Markers; Boston; Case Study; Chemistry; Collaborations; Communication; Community Outreach; Data; Decision Making; Decision Theory; Development; Ecology; Economics; Educational workshop; Ensure; Environment; Environmental Health; Epidemiology; Exposure to; General Population; Genes; Genetic Predisposition to Disease; Goals; Interest Group; Journals; Lead; Mails; Manganese; Metals; Methodology; Oxidation-Reduction; Peer Review; Policies; Policy Developments; Policy Maker; Population; Public Health; Publications; Publishing; Relative (related person); Research; Research Personnel; Research Training; Risk; Risk Assessment; Science Policy; Series; Site; Superfund; Technology; Training Programs; Translating; Translational Research; United States National Institutes of Health; Universities; Work; Writing; base; college; data modeling; environmental toxicology; gene environment interaction; genetic epidemiology; land use; metal poisoning; neurodevelopment; novel; outreach program; policy implication; programs; remediation; sensor; special interest group; symposium; tool; web site

The goal ofthe Research Translation Core is to actively communicate important research findings emanating from the program in the manner most appropriate for the intended audience, with the goal of ensuring the accurate and timely use of data. The Research Translation Core is organized through the Harvard Center for Risk Analysis (HCRA). HCRA, founded in 1989, has always enjoyed extensive collaboration with and support from regulatory agencies, corporations, interest groups, and colleagues at many universities in the US and abroad, and provides an existing base from which to interpret and disseminate research results to a variety of stakeholders and technical audiences. Much of the integration across specific projects and cores is accomplished through HCRA's demonstrated ability to synthesize and interpret research results in terms of relevance to risk-based environmental decision-making. We will evaluate and synthesize the results of the specific projects and cores in terms of the implications for risk assessment and subsequent decisionmaking and policy development using case studies and examples for dissemination through HCRA-led publications, conferences, seminars, workshops, and the SBRP and HCRA websites, as well as through community outreach programs. Potential neurodevelopmental risks as a result of exposure to mixtures of arsenic, manganese, and lead in the environment depend on the mobility and bioavailability of the constituents under different environmental conditions as well as potential genetic susceptibility of exposed populations. The Research Translation Core, through the use of case studies and focused integrative analyses, will demonstrate and communicate the public health implications of changes in bioavailability on exposure, genetic susceptibility relative to population risks, and potential biomarkers of exposure and effect to facilitate risk assessment.

研究翻译核心的目标是以最适合目标受众的方式积极传达该项目的重要研究成果，以确保准确和及时地使用数据。研究翻译核心由哈佛风险分析中心 (HCRA) 组织。 HCRA 成立于 1989 年，一直享有与美国和国外许多大学的监管机构、企业、利益团体和同事的广泛合作和支持，并为向各种利益相关者和技术受众解释和传播研究成果提供了现有基础。跨特定项目和核心的大部分整合是通过 HCRA 所展示的综合和解释研究结果的能力来完成的 与基于风险的环境决策相关。我们将利用案例研究和实例，评估和综合具体项目和核心的结果对风险评估以及后续决策和政策制定的影响，并通过 HCRA 主导的出版物、会议、研讨会、讲习班、SBRP 和 HCRA 网站以及社区外展计划进行传播。暴露于环境中的砷、锰和铅混合物导致的潜在神经发育风险取决于不同环境条件下成分的流动性和生物利用度以及暴露人群的潜在遗传易感性。研究翻译核心将通过案例研究和重点综合分析，展示和传达暴露生物利用度变化、与人群风险相关的遗传易感性以及暴露和影响的潜在生物标志物的公共卫生影响，以促进风险评估。