Research Translation Core

研究翻译核心的目标是以最适合目标受众的方式积极传达项目产生的重要研究成果，以确保准确和及时地使用数据。研究翻译核心由哈佛风险分析中心(HCRA)组织。HCRA成立于1989年，一直得到监管机构、公司、利益集团和美国及海外许多大学的同事的广泛合作和支持，并为向各种利益相关者和技术受众解释和传播研究成果提供了现有的基础。跨特定项目和核心的大部分集成是通过HCRA被证明的综合和解释研究结果的能力来完成的 与基于风险的环境决策相关。我们将使用案例研究和范例来评估和综合具体项目和核心对风险评估和后续决策和政策制定的影响，并通过HCRA牵头的出版物、会议、研讨会、研讨会、SBRP和HCRA网站以及社区外联计划进行传播。暴露在环境中的砷、锰和铅混合物的潜在神经发育风险取决于这些成分在不同环境条件下的流动性和生物利用度，以及暴露人群的潜在遗传易感性。研究翻译核心将通过使用案例研究和重点综合分析，展示和传播生物可获得性变化对公众健康的影响、相对于人口风险的遗传易感性以及潜在的暴露和影响生物标记物，以促进风险评估。

The goal ofthe Research Translation Core is to actively communicate important research findings emanating from the program in the manner most appropriate for the intended audience, with the goal of ensuring the accurate and timely use of data. The Research Translation Core is organized through the Harvard Center for Risk Analysis (HCRA). HCRA, founded in 1989, has always enjoyed extensive collaboration with and support from regulatory agencies, corporations, interest groups, and colleagues at many universities in the US and abroad, and provides an existing base from which to interpret and disseminate research results to a variety of stakeholders and technical audiences. Much of the integration across specific projects and cores is accomplished through HCRA's demonstrated ability to synthesize and interpret research results in terms of relevance to risk-based environmental decision-making. We will evaluate and synthesize the results of the specific projects and cores in terms of the implications for risk assessment and subsequent decisionmaking and policy development using case studies and examples for dissemination through HCRA-led publications, conferences, seminars, workshops, and the SBRP and HCRA websites, as well as through community outreach programs. Potential neurodevelopmental risks as a result of exposure to mixtures of arsenic, manganese, and lead in the environment depend on the mobility and bioavailability of the constituents under different environmental conditions as well as potential genetic susceptibility of exposed populations. The Research Translation Core, through the use of case studies and focused integrative analyses, will demonstrate and communicate the public health implications of changes in bioavailability on exposure, genetic susceptibility relative to population risks, and potential biomarkers of exposure and effect to facilitate risk assessment.