WORKSHOP ON ESR MICROSCOPY AND ITS APPLICATIONS IN BIOMEDICAL ESR IMAGING

ESR 显微镜及其在生物医学 ESR 成像中的应用研讨会

• 批准号: 8364118
• 负责人: Jack H Freed
• 金额: $ 0.16万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364118
• 关键词: Awareness; Biological; Biology; Biomedical Research; Communities; Detection; Development; Educational workshop; Electron Spin Resonance Spectroscopy; Encapsulated; Funding; Future; Grant; Image; Imaging Techniques; Measurement; Medical; Methods; Microscopic; Microscopy; Molecular; National Center for Research Resources; Oxidation-Reduction; Oxygen; Oxygen saturation measurement; Participant; Phase; Physiologic pulse; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Slice; Source; Spin Labels; Technology; Time; United States National Institutes of Health; base; cellular imaging; cost; experience; in vivo; instrumentation; lectures; member; submicron; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. On the basis of encouragement from the ESR community, we presented the 2011 ACERT Workshop on "ESR Microscopy and Its Applications in Biomedical ESR Imaging" this January at the Cornell Main campus in Ithaca . The objective of the workshop was to raise awareness in the biomedical community to the potential of ESR Microscopy, especially in relation to ESR Imaging. Topics included a cross-section of up-to-date ESR Microscopy and ESR Imaging techniques. The workshop included lectures, demonstrations, and "hands-on" experience with the latest ESR Microscopy methods with ample discussions of proposals and plans to integrate the new developments in ESRM with current activities in biomedical ESR Imaging. There were participants from outside of ACERT, ACERT staff members who attended, and 8 outside guest speakers for a total of 30 participants. The invited speakers were: Aharon Blank on "ESR Microscopy - Current Capabilities and Future Directions", Oleg Grinberg on "Climbing to Bio-Med: An Historical Overview", Howard J. Halpern on "The Importance of Understanding the Microscopic Distribution of Trityl Radicals for EPR Oxygen Images", Periannan Kuppusamy on "Molecular and Crystalline Spin Probes Encapsulated in Polymeric Materials for Oxygen Sensing", John Marohn on "Force-Gradient Detection Of Electron Spin Resonance from a Nitroxide Spin Label: A Path to Single-Nitroxide Sensitivity and Applications in Biology", Chang Seok Shin on "Sub-micron Resolution of Pulsed ESR Microscopy and Its Application for Biological/Biomedical Research", Sankaran Subramanian on "Advances in time-domain EPR imaging: Towards slice-selected, globally phase-encoded Echo-based FT-EPR imaging and quantitative in vivo oximetry", and Jay L. Zweier on "New Trityl Probes and their use for Measurement and Imaging of Cellular Oxygenation and Redox State". ACERT was represented by two speakers, Jack H. Freed overviewed "ESR Microscopy at ACERT", and Curt Dunnam talked about "Instrumentation for ESR Microscopy" we are developing at ACERT. The Workshop was considered a success by all participants. Good exchange of ideas occurred between the researchers developing ESR microscopy and those involved in macroscopic medical ESR imaging.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在ESR社区的鼓励下，我们于今年1月在康奈尔大学伊萨卡主校区举办了2011年ACERT研讨会，主题是“ESR显微镜及其在生物医学ESR成像中的应用”。研讨会的目的是提高生物医学界对ESR显微镜潜力的认识，特别是与ESR成像有关的潜力。主题包括最新的ESR显微镜和ESR成像技术的横截面。研讨会包括讲座，演示和最新ESR显微镜方法的“实践”经验，并充分讨论了将ESRM的新发展与生物医学ESR成像的当前活动相结合的建议和计划。有来自ACERT外部的参与者，ACERT工作人员出席，以及8名外部嘉宾演讲者，共30名参与者。 应邀发言的有：Aharon Blank关于“ESR显微镜-当前能力和未来方向”，Oleg Grinberg关于“攀登生物医学：历史综述”，霍华德J. Halpern关于“理解EPR氧图像的三苯甲基自由基的微观分布的重要性”，Perianan Kuppusamy关于“用于氧传感的聚合材料中封装的分子和晶体自旋探针”，John Marohn关于“氮氧自旋标记的电子自旋共振力梯度检测：单氮氧灵敏度和生物学应用之路”，Chang Seok Shin关于“脉冲ESR显微镜的亚微米分辨率及其在生物学/生物医学研究中的应用”，Sankaran Subramanian关于“时域EPR成像的进展：Towards slice-selected，globally phase encoded Echo-based FT-EPR imaging and quantitative in vivo oximetry”，and Jay L. Zweier在“New Trityl Probes and their use for Measurement and Imaging of Cellular Oxygenation and Redox State”上发表的文章。ACERT由两位发言者Jack H. Freed概述了“ACERT的ESR显微镜”，Curt Dunnam谈到了我们正在ACERT开发的“ESR显微镜仪器”。所有与会者都认为讲习班是成功的。 发展ESR显微镜的研究人员和参与宏观医学ESR成像的研究人员之间进行了良好的思想交流。