National Biomedical Center for Advanced ESR Technology (ACERT)

项目摘要/摘要： 这是一份P41更新提案，以继续保留国家先进ESR技术生物医学中心 (Acert)。本课程将强调技术研究与开发的四个主要领域。他们 包括1)高灵敏度脉冲偶极ESR波谱和从X到Ka波段的2D-FT ESR；2)电子 极小生物样品的超高灵敏度自旋共振；3)高灵敏度的发展 4)改进了ESR分析和频谱处理的计算方法。 广泛推动的生物医学项目以及与生物医学研究人员的其他合作将大大受益 来自这些研发和开发，而这又是由DBP对新的和改进的ESR技术的需求推动的。 因此，在研究与开发部门和直接投资伙伴之间存在着重要的协同作用。正在开发的技术 Acert在许多方面都是世界上独一无二的。广泛的DBP和协作/服务项目，请访问 ACERT将继续将这些现代ESR方法带入生物医学研究的前沿，特别是作为 额外的挑战在研发中得到了解决。这包括我们提高光谱灵敏度的计划 在我们的Acert光谱仪中，对它的需求还在继续增长。传播和传播的计划 培训解决了将这些新技术带到美国和其他地方的实验室的需要 除了向外部科学家提供设施外，还出版和宣传 中心，并举办关于新方法的研讨会。

PROJECT SUMMARY/ABSTRACT: This is a P41 renewal proposal to continue the National Biomedical Center for Advance ESR Technology (ACERT). Four principal areas of Technology Research and Development (TR&D) will be emphasized. They consist of 1) High-Sensitivity Pulse Dipolar ESR Spectroscopy and 2D-FT ESR from X to Ka Band; 2) Electron Spin Resonance with Ultra-High Sensitivity for Very Small Biological Samples; 3) Developments in High Frequency ESR, and 4) Improved Computational Methods for ESR Analysis and Spectral Processing. Extensive Driven Biomedical Projects and other collaborations with biomedical researchers will greatly benefit from these TR&Ds, which in turn are driven by the DBP needs for the new and improved ESR technologies. Thus, there is an important synergism amongst the TR&Ds and the DBPs. The technologies being developed at ACERT are in many respects unique in the world. The extensive DBP's and collaborative/service projects at ACERT will continue to bring these modern ESR methods to the forefront of biomedical research, especially as the additional challenges are addressed in the TR&D's. This includes our plans to increase spectral sensitivity in our ACERT spectrometers, for which the demands continue to grow. The plans for dissemination and training address the need to bring these new technologies to other laboratories in the USA and elsewhere in addition to making the facilities available to outside scientists, publishing and advertising the results of the Center and running workshops on the new methodologies.