National Biomedical Center for Advanced ESR Technology (ACERT)

国家生物医学先进ESR技术中心（ACERT）

• 批准号: 9897567
• 负责人: Jack H Freed
• 金额: $ 101.47万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9897567
• 关键词: Acquired Immunodeficiency Syndrome; Address; Advertising; Alzheimer' s Disease; Area; Bacterial Infections; Biological; Biomedical Research; Collaborations; Computing Methodologies; Depressive disorder; Development; Disease; Ebola; Educational workshop; Electron Spin Resonance Spectroscopy; Eye diseases; Frequencies; Heart Diseases; Hypersensitivity; Infertility; Inflammation; Laboratories; Malignant Neoplasms; Methodology; Methods; Modernization; Parkinson Disease; Physiologic pulse; Publishing; Research; Research Personnel; Running; Sampling; Schizophrenia; Scientist; Services; Severe Acute Respiratory Syndrome; Technology; Training; United States National Institutes of Health; Virus Diseases; Wernicke Encephalopathy; combat; improved; nervous system disorder; new technology; protein structure; synergism; technology research and development

PROJECT SUMMARY/ABSTRACT: This is a P41 renewal proposal to continue the National Biomedical Center for Advance ESR Technology (ACERT). Four principal areas of Technology Research and Development (TR&D) will be emphasized. They consist of 1) High-Sensitivity Pulse Dipolar ESR Spectroscopy and 2D-FT ESR from X to Ka Band; 2) Electron Spin Resonance with Ultra-High Sensitivity for Very Small Biological Samples; 3) Developments in High Frequency ESR, and 4) Improved Computational Methods for ESR Analysis and Spectral Processing. Extensive Driven Biomedical Projects and other collaborations with biomedical researchers will greatly benefit from these TR&Ds, which in turn are driven by the DBP needs for the new and improved ESR technologies. Thus, there is an important synergism amongst the TR&Ds and the DBPs. The technologies being developed at ACERT are in many respects unique in the world. The extensive DBP's and collaborative/service projects at ACERT will continue to bring these modern ESR methods to the forefront of biomedical research, especially as the additional challenges are addressed in the TR&D's. This includes our plans to increase spectral sensitivity in our ACERT spectrometers, for which the demands continue to grow. The plans for dissemination and training address the need to bring these new technologies to other laboratories in the USA and elsewhere in addition to making the facilities available to outside scientists, publishing and advertising the results of the Center and running workshops on the new methodologies.

项目概要/摘要： 这是一项 P41 更新提案，旨在继续国家生物医学中心先进 ESR 技术 （ACERT）。将强调技术研究与开发（TR&D）的四个主要领域。他们 包括 1) 高灵敏度脉冲偶极 ESR 光谱和从 X 到 Ka 波段的 2D-FT ESR； 2）电子 对于非常小的生物样品具有超高灵敏度的自旋共振； 3）高中的发展 频率 ESR，以及 4) 改进的 ESR 分析和频谱处理计算方法。 广泛驱动的生物医学项目以及与生物医学研究人员的其他合作将大大受益 这些 TR&D 又是由 DBP 对新的和改进的 ESR 技术的需求驱动的。 因此，TR&D 和 DBP 之间存在重要的协同作用。正在开发的技术 ACERT 在许多方面在世界上都是独一无二的。广泛的 DBP 和协作/服务项目 ACERT 将继续将这些现代 ESR 方法带到生物医学研究的前沿，特别是当 TR&D 解决了额外的挑战。这包括我们提高光谱灵敏度的计划 在我们的 ACERT 光谱仪中，其需求不断增长。传播计划和 培训解决了将这些新技术带到美国和其他地方的其他实验室的需要 除了向外部科学家提供设施外，还出版和宣传研究结果 以新方法为中心并举办研讨会。