INVESTIGATION OF CHARGE-TRANSFER COMPLEXES OF ORTHO- AND PARA- SEMIQUINONES

邻半醌和对半醌的电荷转移络合物的研究

• 批准号: 8364028
• 负责人: DMITRIY TIPIKIN
• 金额: $ 3.82万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364028
• 关键词: Albumins; Biological; Charge; Complex; Cyclodextrins; Fingerprint; Funding; Grant; Investigation; Libraries; National Center for Research Resources; Optics; Principal Investigator; Quercetin; Research; Research Infrastructure; Resources; Source; Structure; Technology; Time; United States National Institutes of Health; Work; charge transfer complex; cost; quantum chemistry; semiquinone; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. High field EPR is a useful tool for investigating change transfer complex formation between unsubstituted o-semiquinones and different organic compounds (quercetin, cyclodextrin, albumin) The formation of charge transfer complexes was verified by observation of the optical spectrum of the charge transfer band. The high-field EPR spectra reveal for the first time a well-resolved g-tensor with a unique fingerprint for every type of complex. Subsequent work will use high-field EPR and quantum chemistry in order to calculate the exact structure of the complex in order to develop a spectral library for identifying various biological molecules containing charge transfer complexes.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 高场EPR是研究未取代的邻半醌与不同有机化合物（槲皮素、环糊精、白蛋白）形成电荷转移络合物的有效工具。电荷转移络合物的形成通过观察电荷转移带的光谱得到证实。 高场EPR谱揭示了第一次一个良好的解决g-张量与独特的指纹，每一种类型的复杂。随后的工作将使用高场EPR和量子化学来计算复合物的确切结构，以开发用于识别包含电荷转移复合物的各种生物分子的光谱库。