MANGANESE IMPURITY SPECTRAL SUBTRACTION PROGRAM

锰杂质光谱减法程序

• 批准号: 8364029
• 负责人: DMITRIY TIPIKIN
• 金额: $ 3.82万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364029
• 关键词: Biological; Computational algorithm; Funding; Grant; Manganese; National Center for Research Resources; Noise; Preparation; Principal Investigator; Relaxation; Research; Research Infrastructure; Resources; Sampling; Signal Transduction; Source; Techniques; Technology; United States National Institutes of Health; Work; cost; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The problem of a strong manganese signal is very well known in high-field EPR. Unfortunately, because of the peculiarities of its spin-lattice relaxation this signal is nearly ubiquitous in biological samples even with careful sample preparation techniques. Since biological samples usually need quite high modulation amplitude to enhance the signal to noise ratio, the narrow impurity lineshape is often overmodulated and it is not easy to subtract the impurity line. We have started work on a computational algorithm to allow for accurate subtraction of the impurity line in order to recover the desired spectrum for subsequent analysis.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 强锰信号的问题在高场 EPR 中是众所周知的。不幸的是，由于其自​​旋晶格弛豫的特殊性，即使采用仔细的样品制备技术，该信号在生物样品中也几乎无处不在。由于生物样品通常需要相当高的调制幅度来增强信噪比，因此窄的杂质线形常常被过调制，并且不容易减去杂质线。我们已经开始研究一种计算算法，以允许精确减去杂质线，以便恢复后续分析所需的光谱。