MANGANESE IMPURITY SPECTRAL SUBTRACTION PROGRAM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在高场电子顺磁共振中，强锰信号的问题是众所周知的。不幸的是，由于其自旋晶格驰豫的特殊性，即使采用了仔细的样品制备技术，这种信号在生物样品中也几乎无处不在。由于生物样品通常需要很高的调制幅度来提高信噪比，因此窄的杂质线形往往被过调制，不容易减去杂质线。我们已经开始了一种计算算法的工作，以允许准确地减去杂质线，以便恢复所需的光谱，以便随后进行分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The problem of a strong manganese signal is very well known in high-field EPR. Unfortunately, because of the peculiarities of its spin-lattice relaxation this signal is nearly ubiquitous in biological samples even with careful sample preparation techniques. Since biological samples usually need quite high modulation amplitude to enhance the signal to noise ratio, the narrow impurity lineshape is often overmodulated and it is not easy to subtract the impurity line. We have started work on a computational algorithm to allow for accurate subtraction of the impurity line in order to recover the desired spectrum for subsequent analysis.