PROTEOMICS AND COMPARATIVE GENOMIC INVESTIGATIONS REVEAL HETEROGENEITY IN EVOLUT

蛋白质组学和比较基因组研究揭示了进化的异质性

• 批准号: 8365865
• 负责人: WILLIE J SWANSON
• 金额: $ 0.65万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365865
• 关键词: Affect; Biology; Characteristics; Employee Strikes; Environment; Female; Funding; Fungal Genome; Grant; Heterogeneity; Histocompatibility Testing; Investigation; Mammals; Mediating; National Center for Research Resources; Physiological; Principal Investigator; Proteins; Proteomics; Research; Research Infrastructure; Resources; Seminal fluid; Source; Tissues; United States National Institutes of Health; cell motility; comparative genomics; cost; fitness; male; reproductive; sperm cell

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Male reproductive fitness is strongly affected by seminal fluid. In addition to interacting with the female environment, seminal fluid mediates important physiological characteristics of sperm, including capacitation and motility. In mammals, the male reproductive tract shows a striking degree of compartmentalization, with at least six distinct tissue types contributing material that is combined with sperm in an ejaculate. While studies of whole ejaculates have been undertaken in some species, we lack a comprehensive picture of the specific proteins produced by different accessory tissues.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 男性的生殖能力受到精液的强烈影响。除了与女性环境相互作用外，精液还调节精子的重要生理特征，包括获能和运动能力。在哺乳动物中，男性生殖道显示出惊人的区隔程度，至少有六种不同的组织类型贡献了与精子结合在一起的射精物质。虽然已经在一些物种中进行了对整个射精的研究，但我们缺乏不同附属组织产生的特定蛋白质的全面图像。