CHOLESTEROL REMOVAL BY HDL PARTICLES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 -HDL被认为是细胞胆固醇的初始受体，并且是胆固醇逆向过程的第一步，胆固醇从细胞膜转运到肝脏以被降解的过程。膜上胆固醇结构域的存在，即所谓的脂筏，将调节胆固醇分子的流出和可及性。 我们研究了这个过程是如何发生的，使用LAURDAN GP成像与双光子激发，并作为一个膜系统在巨单层囊泡和细胞。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. -HDL are considered to be the initial acceptors of cellular cholesterol and the first step in the reverse cholesterol process, the process where cholesterol is transported from the cellular membrane to the liver to be degraded. The existence in the membrane of cholesterol domains, so-called lipd-rafts will regulate the efflux and the accessibility of the sterol molecules. We studied how this process occurs using LAURDAN GP imaging with 2-photon excitation and as a membrane system in Giant Unilamellar Vesicles and cells.