STUDYING HTT PROTEIN AGGREGATION IN CELLS

研究细胞中 HTT 蛋白质聚集

• 批准号: 8365756
• 负责人: ENRICO GRATTON
• 金额: $ 4.5万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-20 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365756
• 关键词: Cells; Fluorescence; Funding; Grant; Image; Laboratories; Length; National Center for Research Resources; Principal Investigator; Process; Proteins; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; polyglutamine; protein aggregation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Imaging the Htt protein aggregation in different cells (COS7, PC12). Studying the different aggregation varying lengths of polyglutamine in the protein. Analyze the dynamics of the process of aggregation.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 成像Htt蛋白在不同细胞(COS7、PC12)中的聚集。研究了聚谷氨酰胺在蛋白质中的不同聚集长度。分析聚集过程的动力学。