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PROJECT H

PROJECT H
项目H
批准号：
8277495
负责人：
Gary A Churchill
金额：
$5.36万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-07-01 至 2016-06-30
来源：
https://reporter.nih.gov/project-details/8277495
关键词：
AnimalsBiochemicalBiochemical PathwayBiochemical ReactionBiological ModelsComplexComputer SimulationDataDietEnzymesEquationGeneticGenetic ModelsGenomeGenotypeGlucoseGlycogenHybridsIndividualInterventionKnowledgeLeadMethionineMethodsModelingMolecularMusPathway interactionsPhenotypeRegulationSimulateSpecific qualifier valueStructureSystemSystems BiologyTestingVariantbasebiological systemsin vivointervention effectmathematical modelmodel developmentresponse

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中文摘要
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英文摘要
Project H: Causal Modeling of Genetic Systems; Gary A Churchill (Jackson) Mathematical modeling is a defining feature of systems biology. Of the many available approaches to modeling, graphical models [117; 118] are unique in their promise to reveal causal relationships and thus to predict response to perturbations based on the correlation structure of multivariate data. Directed graphical models can be inferred from genetic data using genotype as a causal anchor [119;120]. The questions posed here are whether these genotype-driven graphical models can make valid predictions of phenotype and to what extent do the inferred graphical structures reflect the underlying network of biochemical reactions.
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