Curriculum in Experimental Design and Statistics for Biomedical Researchers

项目总结 几十年来，生物医学研究受益于实验设计和统计方法， 赋予研究揭示潜在机制和过程的能力。尽管他们有着悠久的历史和 在研究、实验设计和统计原理方面的授权作用没有得到很好的理解 实验生物学家。我们的目标是增加生物医学研究人员的数量 实验设计和统计通过开发一门课程来提供概念背景 以及声音和可重复性实验的应用实践。为了完善这个课程，我们将测试和 与杰克逊大学的博士后和博士后研究人员一起评估课程 缅因州和康涅狄格州的实验室校园。为了广泛传播课程，我们将把它作为 自学和教学的开放访问许可证下的网站。通过构建、测试和传播 这是一门开放访问的实验设计和统计学课程，我们希望建立统计流畅性 在生物医学研究人员中。通过建立这种流畅性，我们希望这些研究人员找到新的见解 人类疾病的复杂性。因此，生物医学研究将有更大的力量来揭示机制 和过程，这将加快人类疾病研究的进展。

PROJECT SUMMARY For many decades biomedical research has benefitted from experimental design and statistical methods that give studies the power to reveal underlying mechanisms and processes. In spite of their long history and empowering role in research, experimental design and statistical principles are not well understood by experimental biologists. Our goal is to increase the number of biomedical researchers who are fluent in experimental design and statistics by developing a curriculum that provides both the conceptual background and applied practice for sound and reproducible experiments. To refine this curriculum, we will test and evaluate the curriculum with an audience of postdoctoral and predoctoral researchers at the Jackson Laboratory campuses in Maine and Connecticut. To disseminate the curriculum broadly, we will publish it as a website under an open access license for self-study and for teaching. By building, testing, and disseminating an openly accessible curriculum in experimental design and statistics, we expect to build statistical fluency among biomedical researchers. By building this fluency, we expect these researchers to find new insights into the complexity of human disease. As a result biomedical studies will have more power to uncover mechanisms and processes, which will accelerate progress in human disease research.