CORE: HIGH-THROUGHPUT ANALYTICS

核心：高通量分析

• 批准号: 8277497
• 负责人: Gary A Churchill
• 金额: $ 78.41万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8277497
• 关键词: Address; Age; Aliquot; Animals; Autopsy; Biological; Biological Assay; Biological Sciences; Computational Science; DNA; Data; Data Quality; Development; Diabetes Mellitus; Ensure; Equipment; Experimental Designs; Failure; Freezing; Gene Expression; Genome; Genotype; Growth; Heart; Histology; Improve Access; Kidney; Lead; Letters; Libraries; Light; Liver; Measurement; Metabolic; Metabolic syndrome; Methods; Methylation; Microarray Analysis; Mus; Outsourcing; Pancreas; Performance; Phenotype; Preparation; Procedures; Protocols documentation; Recovery; Resources; Running; SNP genotyping; Sampling; Scientist; Services; Techniques; Technology; Time; Tissue Sample; Tissues; Weaning; Work; base; cost; cost effective; data management; density; design; flexibility; interest; mature animal; metabolomics; mouse genome; research study; tool

3.6 High Throughput Analytic Core Dr. Churchill will lead the High Throughput Analytic (HTA) Core. The function of this Core is to coordinate phenotyping activities that span multiple projects to ensure uniformity, efficient use of resources and flexibility in light of rapidly changing technology. The Core extensively leverages Jackson Scientific Services. Dr. Churchill helped to establish the Gene Expression (GES) and Computational Sciences (CS) Services and will work closely with these groups to ensure that services are delivered efficiently at low cost and that the best available technologies are being used to deliver high quality data. The coordination between GES and CS has evolved to be very effective for data management and delivery. The Core will provide access to three critical technologies: RNAseq, targeted metabolite profiling, and high-density SNP genotyping, and it will serve to coordinate the common phenotyping protocols for mice in Projects B, C and D.

3.6高吞吐量分析核心 丘吉尔博士将领导高通量分析(HTA)核心。这个核心的功能是协调 跨多个项目的表型活动，以确保统一、有效利用资源和灵活性 鉴于日新月异的技术。核心广泛利用杰克逊科学服务公司。Dr。 丘吉尔帮助建立了基因表达(GES)和计算科学(CS)服务和意志 与这些小组密切合作，确保以低成本高效提供服务，并确保最好的 现有技术正被用来提供高质量的数据。GES和CS之间的协调有 演变成非常有效的数据管理和交付。核心将提供对三个关键的 技术：RNAseq、靶向代谢物分析和高密度SNP基因分型，它将服务于 协调B、C和D项目中小鼠的通用表型鉴定方案。