Pilot Project

试点项目

• 批准号: 8128146
• 负责人: JOHN J. WOODWARD
• 金额: $ 14.12万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128146
• 关键词: Address; Adopted; Adoption; Affect; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Area; Basic Science; Brain; Clinical Investigator; Clinical Research; Collection; Data; Dependence; Development; Discipline; Emerging Technologies; Experimental Designs; Extramural Activities; Faculty; Funding; Goals; Grant; Heavy Drinking; Individual; Knowledge; Mentors; Mentorship; Mission; Molecular Biology; Molecular Genetics; Monitor; Neurosciences; Pathway interactions; Philosophy; Pilot Projects; Problem Solving; Productivity; Progress Reports; Psychiatry; Psychology; Publications; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Risk Factors; Scientist; System; Technical Expertise; Technology; Testing; Training Support; Translational Research; Translations; Universities; alcohol abuse therapy; alcohol effect; alcohol research; brain behavior; career development; clinical practice; drinking; flexibility; improved; interest; new technology; novel; novel strategies; skills; tool; treatment center; treatment strategy

The major theme of our Alcohol Research Center is treatment through research. By enhancing our basic knowledge of alcohol's action on the brain and of individual risk factors for the development of alcohol abuse and dependence, better treatments can be developed. One important way to facilitate this translation approach to alcohol research is to encourage the development of new tools and ideas. Recent advances in molecular biology and genetics, neuroscience, psychology, psychiatry, and related fields offer great promise for better defining key mechanisms and pathways that underlie excessive drinking. In turn, these targets can be used to develop effective and personalized treatment strategies. The major goal of the ARC Pilot Project Component is to identify and recruit individuals to use these unique tools and skills in order to generate novel and interesting data of relevance to alcohol treatment. This goal will be accomplished by carrying out three Specific Aims: 1) Provide a mechanism to recruit and mentor basic science and clinical investigators into the alcohol research field and to promote their ability to generate publications and independent grant funding; 2) Increase efforts in promoting and developing translational research approaches in the alcohol research field by identifying critical areas where basic science and clinical practice overlap; and 3) Identify gaps in our knowledge regarding the effects of alcohol on brain and behavior, and apply specific technologies and approaches to solving these problems. Each year, we will invite researchers across the MUSC campus to submit a 5-page proposal describing a research plan that specifically addresses novel alcohol treatments or has implications for treatment. A system is in place to review and select pilot projects for funding. Projects supported by this Component will be rigorously monitored for progress, and mentoring will be offered to junior investigators and to those new to the alcohol field. By actively seeking out pilot projects from MUSC researchers across the diverse set of disciplines within the university, we will not only expand our research capabilities, but will provide training and support to investigators who seek to join us in solving the problems associated with alcoholism and excessive drinking.

我们酒精研究中心的主要主题是通过研究来治疗。通过加强我们对酒精对大脑的作用以及导致酒精滥用和依赖的个人风险因素的基本知识，可以开发出更好的治疗方法。促进酒精研究的这种翻译方法的一个重要方法是鼓励开发新的工具和想法。分子生物学和遗传学、神经科学、心理学、精神病学和相关领域的最新进展为更好地界定过度饮酒的关键机制和途径提供了巨大的希望。反过来，这些目标可以 用于制定有效和个性化的治疗策略。 ARC试点项目组成部分的主要目标是确定和招募使用这些独特工具和技能的个人，以便产生与酒精治疗相关的新颖和有趣的数据。这一目标将通过实现三个具体目标来实现：1)提供一个机制，招募和指导酒精研究领域的基础科学和临床研究人员，并提高他们出版出版物和独立资助的能力；2)通过确定基础科学和临床实践重叠的关键领域，加大力度促进和开发酒精研究领域的翻译研究方法；以及3)找出我们在酒精对大脑和行为影响的知识方面的差距，并应用特定技术和方法来解决这些问题。 每年，我们将邀请MUSC校园内的研究人员提交一份5页的提案，描述一项专门针对新型酒精治疗或对治疗有影响的研究计划。已经建立了一个制度来审查和选择试点项目以供资助。将严格监测这一构成部分支持的项目的进展情况，并向初级调查人员和酒精领域的新手提供指导。通过积极寻找南加州大学不同学科研究人员的试点项目，我们不仅将扩大我们的研究能力，还将为寻求加入我们解决与酗酒和过度饮酒相关问题的调查人员提供培训和支持。