APOPTOSIS AND CELL DEATH RESEARCH

细胞凋亡和细胞死亡研究计划的成员将他们的注意力引导到基础 凋亡细胞死亡的分子机制和翻译研究，在一个模型下运行，其中 现代生物医学研究的主要技术(细胞和分子生物学、生物化学、化学和 结构生物学)包含在该计划中。构成细胞核心的所有蛋白质家族 死亡信号是深入涵盖并构成了节目现有的四个主题，从死亡 受体和死亡启动信号复合体(主题1)，到caspase(主题2)，抑制 细胞凋亡蛋白(LAPS；Theme 3)和Bcl2家族成员，包括细胞死亡的整合 线粒体发出信号(主题4)。对非凋亡型细胞的重视程度也越来越高 死亡是一个发展中的主题。过去的资助期也见证了一个强劲的新系列的增长 计划内的协作使用计划成员的综合才能来确定 以抗凋亡蛋白为靶点的分子癌症治疗。该计划的总体目标是 提供一个共享试剂、技术和想法的环境，以促进发现 调控死亡细胞命运决定的基本机制的过程。 自上次续签以来，该方案通过招聘两名新的正式教员和一名 兼职成员，其专业知识与原教员的兴趣相辅相成，并 在快节奏的细胞凋亡和细胞死亡研究领域保持领先地位。盖伊博士 萨尔维森继续担任项目负责人。该计划与联合项目高度协作和互动 实验室会议，研究生和博士后研究员联合指导，每月见习 演讲、每月教职员工会议，以及参与和领导几个项目项目的拨款 以及其他合作筹资机制。结果。与当前的年度总额相比，计划资金非常强劲 赠款资助2290万美元(直接拨款1340万美元)。计划成员领导或参与5个POI(4个来自NCI)， 和10个U54/U19/U01赠款(3个来自NCI)和其他几个联邦和州合作赠款，进一步 证明了计划中的高水平协作活动。程序的生产率通过以下方面得到进一步反映 自上次审查以来的523份出版物，以及2008年的96份计划出版物，占内部和 方案间协作的比例分别为13%。

Members of the Apoptosis & Cell Death Research Program direct their attention towards fundamental molecular mechanisms of apoptotic cell death and translational research, operating under a model where the major technologies of modern biomedical research (cell and molecular biology, biochemistry, chemistry, and structural biology) are encompassed within the Program. All protein families that constitute the core of cell death signaling are covered in depth and constitute the existing four themes of the program, from the death receptors and death initiating signaling complexes (theme 1), to the caspases (theme 2), the Inhibitors of Apoptosis Proteins (lAPs; theme 3), and the Bcl-2 family members, including the integration of cell death signaling by mitochondria (theme 4). Increasing emphasis is also being placed on non-apoptotic forms of cell death as a developing theme. This past funding period has also witnessed the growth of a robust new series of collaborations within the Program that use the combined talents of the program members to identify small molecule cancer therapeutics targeting anti-apoptotic proteins. The overarching objective of the program is to provide an environment where reagents, techniques and ideas are shared to enhance the discovery process of the basic mechanisms that regulate the death cell fate decision. The Program has grown since the last renewal by the recruitment of two new full faculty members and one adjunct member with expertise that complements the interests of the original faculty members, and has maintained a leadership position in the fast-paced field of apoptosis and cell death research. Dr. Guy Salvesen continues as the Program Leader. The Program is highly collaborative and interactive with joint laboratory meetings, joint mentoring of graduate students and postdoctoral fellows, monthly trainee presentations, monthly faculty meetings, and participation and leadership in several Program Project grants and other collaborative funding mechanisms. As a result. Program funding is strong with current total annual grant funding of $22.9MM ($13.4MM direct). Program members lead or participate in 5 POIs (4 from NCI), and 10 U54/U19/U01 grants (3 from NCI) and several other federal and state collaborative grants, further attesting to high-level of collaborative activity in the program. Program's productivity is further reflected by 523 publications since last review, and by 96 Program publications in 2008, which represent 17% of intraand 13% of inter-programmatic collaborations, respectively.