Neurological Emergencies Treatment Trial (NETT) Network Pittsburgh Clinical Hub

描述(由申请人提供)：测试神经疾病治疗的临床试验是降低死亡率和发病率的公共卫生优先事项。为这项测试提供基础设施和减少启动时间的财团将促进Clinica试验的执行，并预先选择具有与特定类型试验相关的特定专业知识的临床地点。匹兹堡大学在研究紧急情况，特别是神经紧急情况方面拥有广泛的资源和专业知识。因此，匹兹堡可以有效地作为神经紧急情况治疗试验(NETT)网络的新临床中心。借助急诊医学、神经学、神经外科、重症护理医学、物理医学和康复之间的长期合作，匹兹堡大学将成功实现以下目标：(目标1)创建一个结构化团队，与NETT网络合作开发和实施有关神经紧急情况的临床试验。匹兹堡NETT团队的领导层将与NETT指导委员会、临床协调中心、数据协调股和NINDS工作人员保持工作关系。(目标2)招募受试者参加NETT临床试验，并传播NETT活动产生的研究成果。匹兹堡将保持行政和合同结构，以迅速参与NETT试验。经验丰富的研究协调员和工作人员将负责确定NETT试验的合格受试者，将根据NETT方案招收受试者，并将保存对合规性进行审计所需的详细记录。将扩大现有的媒体和电子资源，以进一步传播研究成果。 公共卫生相关性：中风、头部损伤和脊柱损伤等神经紧急情况每年导致数百万人死亡和残疾。匹兹堡将会 通过利用其已被证明的招募受试者参加测试紧急治疗的临床试验的能力，为测试这些紧急情况下的新的和有希望的治疗方法做出贡献。

DESCRIPTION (provided by applicant): Clinical trials to test treatments of neurological disorders are a public health priority to reduce mortality and morbidity. Consortiums to provide infrastructure and reduce start-up time for this testing will facilitate the performance of clinica trials and preselect clinical sites with specific expertise relevant for specific types of trials. he University of Pittsburgh has extensive resources and expertise in studying emergency conditions, and specifically neurological emergencies. Therefore, Pittsburgh can serve effectively as a new Clinical Hub for the Neurological Emergencies Treatment Trial (NETT) network. Drawing on longstanding collaborations between Emergency Medicine, Neurology, Neurosurgery, Critical Care Medicine, Physical Medicine and Rehabilitation, the University of Pittsburgh will successfully achieve the following aims: (Aim 1) Create a structured team for collaboration with the NETT Network on the development and implementation of clinical trials about neurological emergencies. The leadership of the Pittsburgh NETT team will maintain working relationships with the NETT steering committee, Clinical Coordinating Center, Data Coordination Unit and NINDS staff. (Aim 2) Enroll subjects in NETT clinical trials and disseminate research findings resulting from NETT activities. Pittsburgh will maintain the administrative and contractual structure to participate rapidly in NETT trials. Experienced research coordinators and staff will be tasked with identification of eligible subjects for NETT trials, will enroll subjects according to NETT protocols, and will maintain the detailed records required for auditing of compliance. Existing media and electronic resources will be expanded to further disseminate research findings. PUBLIC HEALTH RELEVANCE: Neurological emergencies, such as stroke, head injury and spine injury, result in death and disability for millions of individuals each year. Pittsburgh will contribute to the testing of new and promising treatments for these emergencies by using its proven ability to recruit subjects into clinical trials testing emergency treatments.