Neurological Emergencies Treatment Trial (NETT) Network Pittsburgh Clinical Hub

神经急症治疗试验 (NETT) 网络匹兹堡临床中心

• 批准号: 8527867
• 负责人: Clifton W. Callaway
• 金额: $ 30.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8527867
• 关键词: Accident and Emergency department; Acute; Agreement; Area; Caring; Cessation of life; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Computerized Medical Record; Conduct Clinical Trials; Country; Craniocerebral Trauma; Critical Care; Data Coordinating Center; Development; Electronics; Emergency Medicine; Emergency Situation; Emergency treatment; Enrollment; Environment; Faculty; Health system; Hospitals; Individual; Informatics; Informed Consent; Intensive Care Units; Leadership; Learning; Medicine; Mentorship; Modeling; Monitor; Morbidity - disease rate; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; Nervous System Trauma; Neurological emergencies; Neurological outcome; Neurology; Neurosciences; Neurosurgical Procedures; Operative Surgical Procedures; Outcome; Outcome Measure; Patients; Performance; Physical Medicine; Postdoctoral Fellow; Protocols documentation; Qualifying; Records; Recruitment Activity; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Resources; Resuscitation; Rural; Services; Spinal Injuries; Spinal cord injury; Stroke; Structure; System; Telemedicine; Testing; Time; Training; Trauma; Traumatic Brain Injury; Universities; Work; base; career; clinical research site; design; disability; experience; follow-up; member; mortality; nervous system disorder; neurosurgery; next generation; outreach; patient population; programs; public health priorities; tertiary care; treatment trial; waiver

DESCRIPTION (provided by applicant): Clinical trials to test treatments of neurological disorders are a public health priority to reduce mortality and morbidity. Consortiums to provide infrastructure and reduce start-up time for this testing will facilitate the performance of clinica trials and preselect clinical sites with specific expertise relevant for specific types of trials. he University of Pittsburgh has extensive resources and expertise in studying emergency conditions, and specifically neurological emergencies. Therefore, Pittsburgh can serve effectively as a new Clinical Hub for the Neurological Emergencies Treatment Trial (NETT) network. Drawing on longstanding collaborations between Emergency Medicine, Neurology, Neurosurgery, Critical Care Medicine, Physical Medicine and Rehabilitation, the University of Pittsburgh will successfully achieve the following aims: (Aim 1) Create a structured team for collaboration with the NETT Network on the development and implementation of clinical trials about neurological emergencies. The leadership of the Pittsburgh NETT team will maintain working relationships with the NETT steering committee, Clinical Coordinating Center, Data Coordination Unit and NINDS staff. (Aim 2) Enroll subjects in NETT clinical trials and disseminate research findings resulting from NETT activities. Pittsburgh will maintain the administrative and contractual structure to participate rapidly in NETT trials. Experienced research coordinators and staff will be tasked with identification of eligible subjects for NETT trials, will enroll subjects according to NETT protocols, and will maintain the detailed records required for auditing of compliance. Existing media and electronic resources will be expanded to further disseminate research findings.

描述（由申请人提供）：测试神经系统疾病治疗的临床试验是降低死亡率和发病率的公共卫生优先事项。为这种测试提供基础设施和减少启动时间的联盟将促进临床试验的进行，并预先选择具有与特定类型试验相关的特定专业知识的临床地点。匹兹堡大学在研究紧急情况，特别是神经紧急情况方面拥有广泛的资源和专业知识。因此，匹兹堡可以有效地作为神经急症治疗试验（NETT）网络的新临床中心。利用急诊医学、神经病学、神经外科、重症监护医学、物理医学和康复之间的长期合作，匹兹堡大学将成功实现以下目标：（目标1）创建一个结构化的团队，与NETT网络合作，开发和实施有关神经急诊的临床试验。匹兹堡NETT团队的领导将与NETT指导委员会、临床协调中心、数据协调单位和NINDS工作人员保持工作关系。（目标2）招募NETT临床试验的受试者，并传播NETT活动的研究成果。匹兹堡将维持行政和合同结构，以便迅速参与NETT试验。经验丰富的研究协调员和工作人员将负责确定符合条件的受试者进行NETT试验，将根据NETT方案招募受试者，并将保留合规审计所需的详细记录。扩大现有媒体和电子资源，进一步传播研究成果。